{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:10:19Z","timestamp":1790820619061,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This retrospective study aimed to describe and classify cats with intraocular lymphoma, determine the proportion of cases with presumed solitary ocular lymphoma (PSOL) compared with ocular manifestations of multicentric disease and assess the clinical outcomes of these patients. One hundred seventy\u2010two cases identified through biopsy submissions were reviewed histologically; 163 of these cases were subtyped according to the WHO classification system. Cases were categorized as having PSOL or ocular lymphoma with suspected systemic involvement (SSI) based on submission forms and follow\u2010up data. The majority of cases exhibited concurrent uveitis (75%) and secondary glaucoma (58%). Diffuse large B\u2010cell lymphoma was the most common subtype (n\u00a0=\u00a086; 53%), followed by peripheral T\u2010cell lymphoma (n\u00a0=\u00a044; 27%). Other subtypes included anaplastic large T\u2010 (n\u00a0=\u00a08; 5%) and B\u2010cell (n\u00a0=\u00a04; 2.5%) lymphomas, and 15 cases (9%) were negative for all immunohistochemical markers. In sixty\u2010nine cases (40%), adequate clinical data and sufficient survival data were obtained to distinguish PSOL from SSI. PSOL comprised the majority of cases (64%), while 36% had SSI. When covarying for age at diagnosis, the median survival time was significantly higher (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.003) for cases of PSOL (154\u00a0days) versus those with SSI (69\u00a0days); hazards ratio of 0.47 for PSOL (95% CI: 0.241\u20100.937). The subtype of lymphoma did not affect survival time. Cats with PSOL represent a greater proportion of the disease population, and this subset of cats with intraocular lymphoma has a better clinical outcome.\n                  <\/jats:p>","DOI":"10.1111\/vop.12692","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T05:49:45Z","timestamp":1563774585000},"page":"77-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clinical and histopathological classification of feline intraocular lymphoma"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-1144","authenticated-orcid":false,"given":"Ayla R.","family":"Musciano","sequence":"first","affiliation":[{"name":"Department of Pathobiology University of Pennsylvania School of Veterinary Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Lanza","sequence":"additional","affiliation":[{"name":"Department of Pathobiology University of Pennsylvania School of Veterinary Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0977-7364","authenticated-orcid":false,"given":"Richard R.","family":"Dubielzig","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro B. C.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy C.","family":"Durham","sequence":"additional","affiliation":[{"name":"Department of Pathobiology University of Pennsylvania School of Veterinary Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"921","article-title":"Hematopoietic tumors of cats","volume":"17","author":"Hardy WD","year":"1981","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_5_3_1","first-page":"699","volume-title":"Small Animal Clinical Oncology","author":"Vail DM","year":"2007"},{"key":"e_1_2_5_4_1","first-page":"1","article-title":"Ocular manifestation of lymphoma in newly diagnosed cats","author":"Nerschbach V","year":"2013","journal-title":"Vet Comp Oncol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2006.00479.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(90)50064-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-2362-5.00031-1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.4.460"},{"key":"e_1_2_5_9_1","volume-title":"TNM Classification of Tumours in Domestic Animals","author":"Owen LN","year":"1980"},{"key":"e_1_2_5_10_1","first-page":"1","article-title":"Intraocular and periocular lymphoma in dogs and cats: a retrospective review of 21 cases (2001\u20132012)","volume":"17","author":"Ota\u2010Kuroki J","year":"2013","journal-title":"Vet Ophthalmol"},{"key":"e_1_2_5_11_1","first-page":"35","article-title":"Histopathologic features of feline ocular lymphosarcoma: 49 cases (1978\u20131992)","volume":"5","author":"Corcoran KA","year":"1995","journal-title":"Vet Comp Oncol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12492"},{"key":"e_1_2_5_13_1","first-page":"1","article-title":"Canine and feline retinal lymphoma: a retrospective review of 12 cases","volume":"20","author":"Malmberg JL","year":"2016","journal-title":"Vet Ophthalmol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900020205"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1988.10478612"},{"key":"e_1_2_5_16_1","unstructured":"ParkHM.Univariate analysis and normality test using SAS Stata and SPSS. 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