{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:51:38Z","timestamp":1761648698440,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T00:00:00Z","timestamp":1573862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical presentation and outcome of canine patients that present with lipid\u2010laden aqueous humor (LLA) and to evaluate its association with other ocular and systemic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records were identified and reviewed of 30 dogs presenting with clinical signs of LLA between 2013 and 2017 and compared to the canine referral population during the same time period. The percentage of dogs affected by LLA and potential risk factors were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 40 eyes in 30 dogs with LLA out of 8011 (0.4%) referrals. The mean age of dogs with LLA was significantly younger than dogs without LLA (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0334). Sex was not associated with LLA. Miniature Schnauzers were more likely to have LLA than mixed breeds (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). Incidence of LLA was significantly higher in eyes also affected by corneal ulceration (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0018) or phacoemulsification (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0001). Sixty\u2010two percent and 51% of dogs with LLA had concurrent diabetes mellitus and hypertriglyceridemia, respectively. Average triglyceride level of dogs with LLA was 1087\u00a0mg\/dL (\u00b1544) (reference 50\u2010150\u00a0mg\/dL) and average cholesterol level was 575\u00a0mg\/dL (\u00b1232) (reference 125\u2010300\u00a0mg\/dL). Complete resolution of LLA was achieved in all dogs re\u2010examined with an average of 20.2\u00a0days (range 4\u2010175\u00a0days) after diagnosis. There were 6\/30 dogs lost to follow\u2010up. Recurrence of LLA occurred at least once in 4\/24 dogs (16.7%) after resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lipid\u2010laden aqueous humor occurs more frequently in Miniature Schnauzers. Corneal ulceration and phacoemulsification are risk factors. Complete resolution was seen in all cases with a low incidence of recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12719","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T09:03:53Z","timestamp":1573895033000},"page":"277-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A retrospective analysis of lipid\u2010laden aqueous humor in dogs: Thirty cases"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1153-6981","authenticated-orcid":false,"given":"Simone A.","family":"Schechtmann","sequence":"first","affiliation":[{"name":"BluePearl Veterinary Partners Clearwater FL USA"},{"name":"BluePearl Veterinary Partners Sarasota FL USA"},{"name":"BluePearl Veterinary Partners Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Stine","sequence":"additional","affiliation":[{"name":"BluePearl Veterinary Partners Clearwater FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Tampa Bay Veterinary Specialists and Emergency Care Center Largo FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Welihozkiy","sequence":"additional","affiliation":[{"name":"BluePearl Veterinary Partners Sarasota FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-7851","authenticated-orcid":false,"given":"Tammy M.","family":"Michau","sequence":"additional","affiliation":[{"name":"BluePearl Veterinary Partners Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12396"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2008.10.011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1993.tb03519.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.81"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14701"},{"volume-title":"Canine and Feline Endocrinology and Reproduction","year":"2004","author":"Feldman EC","key":"e_1_2_5_7_1"},{"issue":"11","key":"e_1_2_5_8_1","first-page":"1087","article-title":"Idiopathic hyperlipoproteinemia in dogs","volume":"166","author":"Rogers WA","year":"1975","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb01016.x"},{"issue":"9","key":"e_1_2_5_10_1","first-page":"861","article-title":"Lipid\u2010laden aqueous humor associated with anterior uveitis and concurrent hyperlipidemia in two dogs","volume":"168","author":"Olin DD","year":"1976","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1993.tb03522.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12625"},{"key":"e_1_2_5_13_1","first-page":"1153","volume-title":"Veterinary Ophthalmology","author":"Hendrix DH","year":"2013"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.029"},{"issue":"5","key":"e_1_2_5_15_1","first-page":"736","article-title":"Crosslink between lipids and acute uveitis: a lipidomic analysis","volume":"11","author":"Wang HY","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00004-6"},{"key":"e_1_2_5_17_1","first-page":"199","article-title":"Ophthalmological complications of the hypertriglyceridemias","volume":"100","author":"Winder AF","year":"1980","journal-title":"Trans Ophthalmol Soc. 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