{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:15:18Z","timestamp":1781774118144,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate leptospiral antibody prevalence in 65 horses with ERU and compare outcome in 36 surgically treated eyes (2010\u20102015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Retrospective data analysis of horses with ERU (n\u00a0=\u00a065).<jats:italic>C\u2010<\/jats:italic>value calculation with microagglutination assay titer (MAT) results for<jats:italic>Leptospira<\/jats:italic>spp. Evaluation of follow\u2010up data after pars plana vitrectomy (PPV, n\u00a0=\u00a021 eyes) and suprachoroidal cyclosporine device implantation (SCDI, n\u00a0=\u00a015 eyes). Differences between groups were statistically analyzed using Fishers exact test, significance set at<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Positive leptospiral titers were found in 28\/65 blood, 31\/65 aqueous humor (AH), and 19\/20 vitreal (post\u2010PPV) samples. The most common intraocular serovars were<jats:italic>Leptospira interrogans<\/jats:italic>grippotyphosa<jats:italic>,<\/jats:italic>pomona, and bratislava. Intraocular antibody production was suspected in samples of 22 horses (<jats:italic>c<\/jats:italic>\u2010values\u00a0&gt;\u00a01). Mean follow\u2010up of surgical cases was 3.8\u00a0years (PPV) and 3.4\u00a0years (SCDI). PPV was performed in 21 eyes with positive, SCDI in 15 eyes with negative leptospiral test results. Uveitis recurred less often after PPV (2\/21) compared to SCDI (6\/15,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Retinal detachment occurred after PPV only (5\/21, SCDI 0\/15,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.06), whereas only SCDI\u2010treated eyes were enucleated (PPV 0\/21, SCDI 3\/15,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.06). Blindness or visual impairment was equally likely to occur in both treatment groups after surgery (PPV 7\/21, SCDI 7\/15,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Leptospiral antibody prevalence is high in horses with ERU in Switzerland. Recurrence of uveitis is uncommon following PPV in the present study; an increased risk of retinal detachment exists. Enucleation is more often warranted in horses after SCDI in this study due to a higher uveitis recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12767","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T19:08:13Z","timestamp":1588273693000},"page":"648-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Leptospiral antibody prevalence and surgical treatment outcome in horses with Equine Recurrent Uveitis (ERU) in Switzerland"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6349-6782","authenticated-orcid":false,"given":"Katrin","family":"Voelter","sequence":"first","affiliation":[{"name":"Veterinary Ophthalmology Equine Clinic Vetsuisse Faculty Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Vial","sequence":"additional","affiliation":[{"name":"Veterinary Ophthalmology Equine Clinic Vetsuisse Faculty Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Pot","sequence":"additional","affiliation":[{"name":"Veterinary Ophthalmology Equine Clinic Vetsuisse Faculty Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard M.","family":"Spiess","sequence":"additional","affiliation":[{"name":"Private Practice Wolfe Island Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12451"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.tb05636.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.tb05635.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(99)00082-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00625.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.2460\/javma.1995.207.10.1327","article-title":"Association of leptospiral seroreactivity and breed with uveitis and blindness in horses: 372 cases (1986\u20131993)","volume":"207","author":"Dwyer AE","year":"1995","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1863-2378.2011.01445.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.11.7259-7266.2005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.7.2731-2733.2000"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870701900611"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.795"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2007.00921.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12129"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071619"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.02.027"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12693"},{"key":"e_1_2_7_18_1","first-page":"948","article-title":"Experimental chronic uveitis. 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