{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:26:09Z","timestamp":1788877569474,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of dorzolamide 2% ophthalmic solution on serum potassium and other hematologic parameters in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Part I<\/jats:italic>\n                      : Medical records from a single institution were retrospectively reviewed. Inclusion criteria consisted of cats diagnosed with glaucoma for which appropriate clinicopathological data were available both prior to and after the initiation of therapy with dorzolamide 2% ophthalmic solution.\n                      <jats:italic>Part II<\/jats:italic>\n                      : Healthy adult cats were enrolled in a prospective double\u2010masked, randomized, cross\u2010over study. Either dorzolamide 2% ophthalmic solution or placebo was administered OU t.i.d. for 6\u00a0weeks. Serum potassium, sodium, chloride, glucose, ALP, and ALT levels were assessed every 2\u00a0weeks. After a 2\u2010week washout period, each cat was given the opposite topical preparation, and the study process was repeated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Part I<\/jats:italic>\n                      : Of the twenty\u2010seven eligible cases, hypokalemia developed in 29.6% (n\u00a0=\u00a08). While female spayed cats were significantly more likely to become hypokalemic, serum potassium was not significantly affected by age, weight, dosing frequency, or number of eyes treated.\n                      <jats:italic>Part II<\/jats:italic>\n                      : Ten cats participated in the study. Potassium values were significantly lower in cats receiving dorzolamide 2% ophthalmic solution compared to placebo at each time point throughout the 6\u2010week study period. Additionally, chloride values were significantly greater in the treatment group at week two and four compared to the placebo group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Administration of dorzolamide 2% ophthalmic solution has a measurable effect on serum potassium level in cats and may result in clinical hypokalemia. Therefore, routine electrolyte monitoring is advised for feline patients receiving this medication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.12773","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T11:27:27Z","timestamp":1603279647000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hypokalemia associated with topical administration of dorzolamide 2% ophthalmic solution in cats"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-7379","authenticated-orcid":false,"given":"Tara M.","family":"Czepiel","sequence":"first","affiliation":[{"name":"Eye Care for Animals Wheeling Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal T","family":"Wasserman","sequence":"additional","affiliation":[{"name":"Eye Care for Animals Wheeling Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1050","volume-title":"Veterinary Ophthalmology","author":"Plummer CE","year":"2013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(80)50034-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12417"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-0750-9_1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241030-00004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1979.tb00378.x"},{"key":"e_1_2_7_8_1","first-page":"792","article-title":"Effects of acetazolamide on blood acid\u2010base and electrolyte values in dogs","volume":"179","author":"Haskins SC","year":"1981","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00053-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(88)33110-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74987-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6436.21"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1977.04450080088009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.283.6305.1527"},{"key":"e_1_2_7_15_1","unstructured":"TofflemireKL.Metabolic acidosis and hypokalemia associated with topical carbonic anhydrase inhibitor therapy in two cats. Presented at 44th Annual American College of Veterinary Ophthalmologists Meeting; November 4\u20139th 2013; Puerto Rico.http:\/\/events7.mediasite.com\/Mediasite\/Play\/59fcc762fd314145a36e1065fad0f2421d. 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