{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:35:46Z","timestamp":1788593746261,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the effects of chronic, uncontrolled glaucoma on pressure sensitivity in dogs before and after enucleation of the painful globe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Client\u2010owned dogs undergoing enucleation for chronic glaucoma with no other sources of pain were enrolled. Normal dogs of similar breeds and skull morphology were enrolled as controls. Craniofacial ratio (CFR) and relative palpebral fissure width (RPFW) were assessed in all patients. Serial mechanical quantitative sensory testing (QST) was performed the day before surgery, and 14, 30, 60, and 120\u00a0days after surgery. QST consisted of electronic Von Frey (eVF), and blunt algometry (BA) performed above and below the nonglaucomatous eye, the metacarpus, and metatarsus. Cochet\u2010Bonnet esthesiometry (CB) was also performed on the remaining eye.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve dogs (6 per group) were included. Compared to baseline values, sensitivity tended to decrease over time (increased thresholds) in treatment dogs while it stayed constant or increased slightly in control dogs. The difference in change from baseline sensitivity between control and treatment groups was significant at day 120 using BA at supraorbital (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0153), infraorbital (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0209), and metacarpal sites (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.007) and overall (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0470). This divergence was also significant using CB (<jats:italic>P\u00a0=\u00a0<\/jats:italic>.0470) on the opposite cornea. As patient CFR and RPFWV increased, both eVF (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005\u2010.023) and BA (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004\u2010.041) increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sensitivity to mechanical stimuli decreased both locally and at remote sites in dogs following enucleation for painful chronic glaucoma. Cranial conformation is associated with differences in sensitivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12800","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T08:30:45Z","timestamp":1593592245000},"page":"116-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Glaucoma\u2010associated pain results in mechanical sensitivity changes in dogs: A pilot study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-9420","authenticated-orcid":false,"given":"Ashley E.","family":"Zibura","sequence":"first","affiliation":[{"name":"Comparative Ophthalmology Department of Clinical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacklyn H.","family":"Salmon","sequence":"additional","affiliation":[{"name":"Comparative Ophthalmology Department of Clinical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Belda Lopez","sequence":"additional","affiliation":[{"name":"Small Animal Surgery Department of Clinical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"},{"name":"Translational Research in Pain Program Department of Clinical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-9009","authenticated-orcid":false,"given":"B. 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