{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:46:17Z","timestamp":1788781577372,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the effect of intrsacameral epinephrine on heart rate, blood pressure, post\u2010operative ocular hypertension, and complications following canine phacoemulsification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>A prospective, double\u2010blinded, controlled trial was carried out using 30 client\u2010owned dogs undergoing phacoemulsification. Eyes were randomly assigned to a treatment group receiving intracameral (IC) epinephrine (n\u00a0=\u00a031) or balanced salt solution (n\u00a0=\u00a025) at the beginning of surgery. Heart rate, post\u2010operative intraocular pressures, and outcomes were compared between treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No adverse reactions to IC epinephrine or saline were observed. Post\u2010operative ocular hypertension developed at the 2 and\/or 4\u00a0hours pressure reading in 35% and 46% in the epinephrine and saline groups, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.5072). There were 9.7% and 23.1% eyes that developed complications in the IC epinephrine and saline groups, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.2373).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intracameral epinephrine is safe to use, and non\u2010significant decreases in post\u2010operative ocular hypertension and long\u2010term complications were observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12812","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T19:56:39Z","timestamp":1597866999000},"page":"872-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of intracameral epinephrine on heart rate, post\u2010operative ocular hypertension, and long\u2010term outcome following canine phacoemulsification"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0933-291X","authenticated-orcid":false,"given":"Stephanie C.","family":"Osinchuk","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Science Western College of Veterinary Medicine University of Saskatchewan Saskatoon SK Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse M.","family":"Salpeter","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science Western College of Veterinary Medicine University of Saskatchewan Saskatoon SK Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Lavallee","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science Western College of Veterinary Medicine University of Saskatchewan Saskatoon SK Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina L.","family":"Leis","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science Western College of Veterinary Medicine University of Saskatchewan Saskatoon SK Canada"},{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5852-9308","authenticated-orcid":false,"given":"Lynne S.","family":"Sandmeyer","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science Western College of Veterinary Medicine University of Saskatchewan Saskatoon SK Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1254","volume-title":"Veterinary Ophthalmology","author":"Wilkie D","year":"2013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-3429-9.00002-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2011.12.1.99"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31281-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1987.tb07030.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(97)90138-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.135.13.306"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12588"},{"key":"e_1_2_7_10_1","first-page":"487","article-title":"The effect of topical 1\u2010epinepherine on regional ocular blood flow in monkeys","volume":"19","author":"Alm A","year":"1980","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_11_1","first-page":"2672","article-title":"Epinephrine increases facility of outflow and cyclic AMP content in the human eye in vitro","volume":"33","author":"Erickson\u2010Lamy KA","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1994.10.241"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2460\/javma.1996.209.01.105","article-title":"Ocular hypertension following cataract surgery in dogs:139 cases (1992\u20131993)","volume":"209","author":"Smith PJ","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.0033.x"},{"key":"e_1_2_7_15_1","first-page":"83","article-title":"Effects of topical 1\u2010epinephrine and dipivalyl epinephrine on intraocular pressure and pupil size in the normotensive and glaucomatous Beagle","volume":"39","author":"Gwin RM","year":"1978","journal-title":"Am J Vet Res"},{"key":"e_1_2_7_16_1","unstructured":"KaneSP.Sample size calculator ClinCalc LLC.https:\/\/clincalc.com\/stats\/samplesize.aspx. Accessed September 19 2019."}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.12812","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T03:26:26Z","timestamp":1723433186000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,19]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/vop.12812"],"URL":"https:\/\/doi.org\/10.1111\/vop.12812","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,19]]},"assertion":[{"value":"2020-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}