{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:47:43Z","timestamp":1790628463767,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe a modified keratoleptynsis procedure, as a method of preserving central corneal function, and evaluate the outcome in vision, reduction of corneal thickness and treatment of epithelial corneal ulcers in cases with endothelial cell dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four dogs (72 eyes) were affected by progressive corneal edema, with or without ulcerative keratitis. All patients were treated with a dorsal and ventral superficial keratectomy followed by conjunctival flaps, maintaining a clear central cornea. Corneal thickness measurements were obtained via ultrasound biomicroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All eyes showed resolution of ocular discomfort postoperatively, with a median time to resolution of 35\u00a0days. Two years post\u2010surgery, vision had been lost in 2 of 29 eyes (7%). From the initial population, 23 dogs (39 eyes) had follow\u2010up evaluations of corneal thickness. The mean central corneal thickness was 1359\u00a0\u00b1\u00a0251\u00a0\u03bcm prior to surgery. Thickening of the central cornea was observed one week after surgery to 1559\u00a0\u00b1\u00a0263\u00a0\u03bcm. Decreased corneal thickness was reported, at 1\u00a0month, 4\u00a0months, 10\u00a0months and 2\u00a0years postoperatively (1285\u00a0\u00b1\u00a0267\u00a0\u03bcm, 1102\u00a0\u00b1\u00a0150\u00a0\u03bcm, 1121\u00a0\u00b1\u00a0288\u00a0\u03bcm, 1193\u00a0\u00b1\u00a0283\u00a0\u03bcm, respectively). All eyes showed a similar trend of increasing and then decreasing corneal thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This surgical technique provided statistically significant reduction in central corneal thickness and sustained relief of ocular pain. Reduction in corneal thickness appeared to be maintained 2\u00a0years post\u2010surgery, and all patients remained comfortable. Superficial corneal pigmentation and fibrosis resulted in vision loss in two eyes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12823","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T07:43:13Z","timestamp":1606722193000},"page":"930-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A modified technique of keratoleptynsis (\u201cletter\u2010box\u201d) for treatment of canine corneal edema associated with endothelial dysfunction"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3775-7659","authenticated-orcid":false,"given":"Stamatina","family":"Giannikaki","sequence":"first","affiliation":[{"name":"Optivet Referrals Havant UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Escanilla","sequence":"additional","affiliation":[{"name":"Optivet Referrals Havant UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit","family":"Sturgess","sequence":"additional","affiliation":[{"name":"Vet Freedom Ltd Brockenhurst UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Optivet Referrals Havant UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,6]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Veterinary ophthalmology","author":"Gelatt KN","year":"2013"},{"key":"e_1_2_7_3_1","first-page":"267","article-title":"Decrease in canine corneal endothelial cell density and increase in corneal thickness as functions of age","volume":"22","author":"Gwin RM","year":"1982","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001431"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18885"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12504"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1139"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(90)50057-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.1999.00408.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(93)90099-S"},{"issue":"2","key":"e_1_2_7_11_1","first-page":"405","article-title":"Therapeutic efficacy of 5% NaCl hypertonic solution in patients with bullous keratopathy","volume":"30","author":"Knezovi\u0107 I","year":"2006","journal-title":"Coll Antropol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12582"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001823"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32589-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100130646002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181ca369a"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200205000-00002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000214225.98366.83"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.07.024"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.607"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20120830-01"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12280"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12137"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12617"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12611"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000966"},{"key":"e_1_2_7_27_1","unstructured":"GuerreiroCE LoweR.A novel surgical approach to canine bullous keratopathy. 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