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The animal was evaluated ophthalmologically and systemically, and hematological, microbiological, and conjunctival cytological and biopsy samples were collected for complementary diagnosis. The histopathological examination showed amphophilic intranuclear inclusions associated with severe inflammatory infiltrate. The diagnosis of <jats:italic>Chelonid alphaherpesvirus<\/jats:italic> 5 (ChAHV 5) was confirmed with end point PCR. Following systemic treatment with L\u2010lysine, acyclovir and vitamin A, the ocular signs resolved. No amphophilic intranuclear inclusions were seen in a follow\u2010up biopsy 5\u00a0months later, and there has been no recurrence of clinical ophthalmic signs during a 4\u2010year follow\u2010up. It is suggested that ChAHV 5 be considered as a differential diagnosis in captive marine turtles that present for conjunctival disease other than fibropapillomatosis.<\/jats:p>","DOI":"10.1111\/vop.12837","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T02:12:16Z","timestamp":1602727936000},"page":"97-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Atypical ocular Chelonoid herpesvirus manifestations in a captive Loggerhead turtle (<i>Caretta caretta<\/i>)"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5093-6841","authenticated-orcid":false,"given":"Arianne P.","family":"Ori\u00e1","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine and Zootechny Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle N.","family":"Silva","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Zootechny Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cl\u00e1udia","family":"Raposo","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Zootechny Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Estrela\u2010Lima","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Zootechny Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds T.","family":"Pires","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010TAMAR National Coordination Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"Gattamorta","sequence":"additional","affiliation":[{"name":"Laboratory of Wildlife Comparative Pathology Department of Pathology School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta R.","family":"Zamana","sequence":"additional","affiliation":[{"name":"Laboratory of Wildlife Comparative Pathology Department of Pathology School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana R.","family":"Matushima","sequence":"additional","affiliation":[{"name":"Laboratory of Wildlife Comparative Pathology Department of Pathology School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-3113","authenticated-orcid":false,"given":"Ron","family":"Ofri","sequence":"additional","affiliation":[{"name":"The Koret School of Veterinary Medicine Hebrew University of Jerusalem Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"CasaleP TuckerAD.Caretta caretta Loggerhead Turtle. 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