{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:43:33Z","timestamp":1766580213144,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T00:00:00Z","timestamp":1606608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Determine the immediate post\u2010operative effects of MicroPulse<jats:sup>\u2122<\/jats:sup> transscleral cyclophotocoagulation (MP\u2010TSCPC) in healthy equine eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>Ten adult horses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MP\u2010TSCPC was performed on sedated horses in 12 eyes (4 groups) using the following parameters (power, duration, duty cycle): (1) 2000\u00a0mW, 180\u00a0seconds, 31.3%; (2) 3000\u00a0mW, 180\u00a0seconds, 31.3%; (3) 3000\u00a0mW, 270\u00a0seconds, 31.3%; and (4) 3000\u00a0mW, 270\u00a0seconds, 50%. Three additional eyes were left untreated (control). Eyes were monitored clinically until euthanasia (mean\u00a0=\u00a03\u00a0hours post\u2010procedure). Histologic sections were assessed with light microscopy and transmission electron microscopy (TEM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MP\u2010TSCPC was well tolerated by sedated horses. Adverse effects were only noted in Group 4: ocular hypertension (n\u00a0=\u00a03\/3), conjunctival burns (3\/3), aqueous flare (2\/3), and a corneal erosion (1\/3). Histologic scoring of Group 4 was statistically greater than other treated groups (1\u20103) and control eyes (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.021). TEM showed subtle changes to the mitochondria and plasma membrane infoldings of the basilar surface of the nonpigmented epithelium in all treated eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MP\u2010TSCPC does not cause immediate post\u2010procedure adverse clinical effects or pronounced morphological changes to the ciliary body, except with the highest laser settings evaluated (power 3000\u00a0mW, duration 270\u00a0seconds, duty cycle 50%).<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12846","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T19:34:15Z","timestamp":1606678455000},"page":"59-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Histologic effects of MicroPulse\u2122 transscleral cyclophotocoagulation in normal equine eyes"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-6122","authenticated-orcid":false,"given":"Braidee C.","family":"Foote","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine Iowa State University Ames IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7952-8024","authenticated-orcid":false,"given":"Jodi D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology College of Veterinary Medicine Iowa State University Ames IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-7004","authenticated-orcid":false,"given":"Rachel A.","family":"Allbaugh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine Iowa State University Ames IA 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