{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:53:35Z","timestamp":1782464015998,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety and efficacy of unilateral topical application of rocuronium bromide in scops owls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>Ten healthy adult scops owls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Birds weighting between 82\u2010111\u00a0g were enrolled. Complete physical and ophthalmic examinations were performed. Each animal received a single dose of 0.15\u00a0mg of rocuronium bromide (30\u00a0\u00b5L) in a randomly selected eye. Static pupillometric evaluations were performed before and after drug instillation at 0, 30, 60, 90, and 120\u00a0minutes, in a room with fixed light intensity. Physical and ophthalmic examinations were carried out to evaluate possible adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median pupil (95% CI) size at<jats:italic>t<jats:sub>0<\/jats:sub><\/jats:italic>was 7.10\u00a0mm (5.51\u20107.41) for placebo eyes and 7.22\u00a0mm (6.93\u20107.48) for treated eyes, showing no statistical differences (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). When compared to the placebo eye, significant mydriasis was achieved at<jats:italic>t<jats:sub>30<\/jats:sub><\/jats:italic>[8.18\u00a0mm (7.22\u20109.00)] (<jats:italic>P\u00a0=\u00a0<\/jats:italic>.014) and lasting until<jats:italic>t<jats:sub>90<\/jats:sub><\/jats:italic>[7.35\u00a0mm (6.20\u20109.52)] (<jats:italic>P\u00a0=\u00a0<\/jats:italic>.004). Maximal mydriasis was obtained at<jats:italic>t<jats:sub>60<\/jats:sub><\/jats:italic>[8.63\u00a0mm (7.72\u20109.81)] (<jats:italic>P\u00a0=\u00a0<\/jats:italic>.001). During this period, the treated eye no longer responded to direct light stimulation. Complete mydriasis was observed in 5\/10 birds (mean weight 97.4\u00a0g). Pupil size at<jats:italic>t<jats:sub>90<\/jats:sub><\/jats:italic>and<jats:italic>t<jats:sub>120<\/jats:sub><\/jats:italic>did not differ from baseline (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05) in treated eyes. No adverse effects were seen during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Single\u2010dose topical rocuronium bromide (0.15\u00a0mg) is a safe and effective medium duration mydriatic agent in scops owls. Further studies are needed to evaluate bilateral topical application and standardize the mydriatic protocol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12856","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T09:01:27Z","timestamp":1609923687000},"page":"169-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Safety and efficacy of unilateral topical application of rocuronium bromide in healthy scops owls (<i>Otus scops<\/i>)"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2516-7750","authenticated-orcid":false,"given":"Francisco","family":"Cantero","sequence":"first","affiliation":[{"name":"Servei d\u2019Oftalmologia Fundaci\u00f3 Hospital Cl\u00ednic Veterinari Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"},{"name":"Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2770-4617","authenticated-orcid":false,"given":"\u00c1ngel","family":"Ortill\u00e9s","sequence":"additional","affiliation":[{"name":"Servei d\u2019Oftalmologia Fundaci\u00f3 Hospital Cl\u00ednic Veterinari Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"},{"name":"Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-5566","authenticated-orcid":false,"given":"Mar\u00eda T.","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Servei d\u2019Oftalmologia Fundaci\u00f3 Hospital Cl\u00ednic Veterinari Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"},{"name":"Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-5281","authenticated-orcid":false,"given":"Savina","family":"Gogova","sequence":"additional","affiliation":[{"name":"Servei d\u2019Oftalmologia Fundaci\u00f3 Hospital Cl\u00ednic Veterinari Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"},{"name":"Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Molina","sequence":"additional","affiliation":[{"name":"Centre de Recuperaci\u00f3 de la Fauna Salvatge de la Torreferrusa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Laboratory of Biostatistics &amp; Epidemiology Facultat de Medicina Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"},{"name":"Hospital Cl\u00ednic Biostatistics and Data Management Platform (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-0946","authenticated-orcid":false,"given":"Marta","family":"Leiva","sequence":"additional","affiliation":[{"name":"Servei d\u2019Oftalmologia Fundaci\u00f3 Hospital Cl\u00ednic Veterinari Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"},{"name":"Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria Universitat Aut\u00f2noma de Barcelona Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Handbook of the Birds of the World. 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