{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:23:16Z","timestamp":1771518196120,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the prevalence of ocular fundus abnormalities in cats with a diagnosis of systemic hypertension, to characterize the abnormalities observed, and to evaluate ophthalmoscopic evolution during treatment with amlodipine besylate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>Cats diagnosed as affected by SHP in a 2\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Systemic hypertension was assessed by oscillometric blood pressure measurement, and its etiology was also established. All the cats received an ophthalmic examination, and ocular lesions were classified with a score from 0 (no abnormalities) to 4 (severe abnormalities). All cats received amlodipine<jats:bold>besylate<\/jats:bold>by mouth, and those that showed fundus abnormalities were regularly rechecked from 7 to 365\u00a0days after diagnosis. Data were statistically analyzed to compare P<jats:sub>sys<\/jats:sub>and P<jats:sub>dia<\/jats:sub>with all the variables and to correlate P<jats:sub>sys<\/jats:sub>and P<jats:sub>dia<\/jats:sub>with the fundus score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 225 cats were enrolled in the study, and the prevalence of fundus abnormalities was 58.6% (21.2%: grade 1; 18.2%: grade 2; 36.4%: grade 3; and 24.2%: grade 4). Systemic hypertension was diagnosed concurrently with chronic renal failure (60.4%), hyperthyroidism (28.9%), both chronic renal failure and hyperthyroidism (7.6%), and hypertrophic myocardiopathy (3.1%). A significant effect of P<jats:sub>sys<\/jats:sub>values on the fundus score was detected. Amlodipine therapy improved fundus abnormalities in 50% of cases at the 21\u2010day follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that fundus abnormalities are common in hypertensive cats at the time of the systemic diagnosis, and most of the abnormalities are moderate to severe. Treatment with amlodipine appeared to improve ophthalmic lesions over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12862","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T13:11:20Z","timestamp":1611925880000},"page":"185-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ocular fundus abnormalities in cats affected by systemic hypertension: Prevalence, characterization, and outcome of treatment"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-2182","authenticated-orcid":false,"given":"Alessandro","family":"Cirla","sequence":"first","affiliation":[{"name":"Department of Ophthalmology San Marco Veterinary Clinic and Laboratory Veggiano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Drigo","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Production and Health University of Padova Legnaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Andreani","sequence":"additional","affiliation":[{"name":"Independent Professional Ophthalmology Limited Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Barsotti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Pisa S. 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