{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:12:11Z","timestamp":1770837131291,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This prospective pilot study was conducted to evaluate the outcome of a commercially available corneal stroma substitute, Acellular Porcine Corneal Stroma (APCS), in dogs undergoing penetrating keratoplasty (PK) to restore corneal integrity after having deep ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Five dogs (1 eye in each dog) underwent a PK using APCS (BioCorneaVet\u2122) as a graft. The surgical procedure and peri\u2010 and postoperative treatment were standardized. All cases required a minimum 6\u00a0months follow\u2010up. Ease of keratoprosthetic tissue handling, graft survival, anterior chamber stability, corneal opacity, neovascularization and re\u2010epithelialization were noted. Presence of secondary uveitis was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BioCorneaVet\u2122 was easy to handle and, at all\u2010time points, provided adequate tectonic support. Graft survival was achieved in all 5 cases. A minimum follow\u2010up period of 10\u00a0months was available for the five eyes (22\u00a0months maximum). Degree and area of corneal graft opacity progressively improved resulting in minimal to moderate loss of transparency in all cases but one, where it was severe. Neovascularization degree was most severe 0.5\u20131\u00a0month after surgery and fully resolved 4\u20136\u00a0months post\u2010surgery. Re\u2010epithelialization was complete in the majority of grafts in 1\u00a0month. Secondary uveitis was not detected at any time in 4 of 5 dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BioCorneaVet\u2122 seems to be an effective graft for PK in the dog. In this case series, APCS was convenient to handle during surgery and provided excellent tectonic support. The material showed good tissue biocompatibility and resulted in the majority of cases in minimal to moderate graft opacity, that ameliorates with time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12884","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T18:03:42Z","timestamp":1616954622000},"page":"543-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Penetrating Keratoplasty in Dogs using Acellular Porcine Corneal Stroma (BioCorneaVet\u2122): A prospective pilot study of five cases"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7415-0584","authenticated-orcid":false,"given":"Arnold","family":"Lavaud","sequence":"first","affiliation":[{"name":"Ophthalmology Unit Vetsuisse Faculty Equine Department University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malwina Ewa","family":"Kowalska","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Vetsuisse Faculty Equine Department University of Zurich Zurich Switzerland"},{"name":"Section of Epidemiology Vetsuisse Faculty University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6349-6782","authenticated-orcid":false,"given":"Katrin","family":"Voelter","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Vetsuisse Faculty Equine Department University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon A.","family":"Pot","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Vetsuisse Faculty Equine Department University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Rampazzo","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Vetsuisse Faculty Equine Department University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12392"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12228"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00052.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12326"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12643"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12193"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12047"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2001.00192.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-02192-z"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12566"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12509"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13096"},{"key":"e_1_2_7_15_1","unstructured":"MicceriD SapienzaJS daSilvaEG GuandaliniA.The Use of a Bio\u2010Engineered Porcine Acellular Corneal Graft for the Treatment of Deep Corneal Deffects in Dogs and Cats; 23 Eyes (abstract).The 50th Annual Scientific Meeting of the American College of Veterinary Ophthalmologists. . 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