{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:27:39Z","timestamp":1781659659824,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the effect of prophylactic anti\u2010malarial chloroquine treatment, and its cessation, on electroretinographic (ERG) responses of captive African penguins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A brief ERG protocol (\u201cQuickRetCheck\u201d) was recorded under mesopic conditions with manual restraint and no sedation or pupil dilation. Birds were recorded on two separate occasions, first while being treated with a daily chloroquine dose of 10\u00a0mg\/kg for 12\u00a0days (<jats:italic>n<\/jats:italic>\u00a0=\u00a015, treatment group) and second after 4\u00a0months without chloroquine treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a06, off\u2010treatment group). Three birds were recorded on both occasions. Three other birds from the flock that died were studied histopathologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Scotopic responses were unmeasurable in either recording and therefore were not analyzed. Mean a\u2010 and b\u2010wave amplitudes of the mixed rod\u2010cone responses to standard (3\u00a0cd\u00b7s\/m<jats:sup>2<\/jats:sup>) and high (10\u00a0cd\u00b7s\/m<jats:sup>2<\/jats:sup>) intensity flashes were higher in the off\u2010treatment group. No difference in implicit times was observed. Sex, age, and number of previous chloroquine treatments did not affect ERG responses. Histopathology revealed<jats:italic>Plasmodium<\/jats:italic>spp.in the lungs, liver, and brain, but not in the eyes, of the necropsied birds, and there were no signs of retinitis or retinopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Daily chloroquine treatment was associated with attenuated ERG responses in penguins, which improve following cessation of treatment. Further work is warranted to establish a chloroquine dose that is efficacious yet has minimal adverse effects. Our results suggest that ERG responses of captive penguins undergoing ERG for any indication (such as prior to cataract surgery), must be evaluated in light of the birds' anti\u2010malaria treatment status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12890","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T13:54:50Z","timestamp":1619445290000},"page":"336-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment with chloroquine is retinotoxic in captive African penguins (<i>Speniscus demersus<\/i>). 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