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Reducing IOP is the only treatment proven to be effective at delaying disease progression. Nevertheless, even when patients have their IOP reduced, the majority of them continue to lose vision. There are, in both humans and dogs, significant interindividual variabilities in susceptibilities to IOP\u2010induced optic nerve damage. Vision loss progresses much more slowly in Beagles with open\u2010angle glaucoma (OAG) caused by<jats:italic>ADAMTS10<\/jats:italic>\u00a0mutation. This can be attributed to the mutation\u2010related altered ocular biomechanical properties. The principal site of optic nerve (ON) damage in glaucoma is the ONH. It is suggested that the biomechanical properties of the ONH and the surrounding peripapillary sclera (PPS) contribute to glaucoma development and progression. As far as the beneficial biomechanical properties of the ONH and PPS for a decreased susceptibility and slow progression of glaucoma, data are inconsistent and conflicting. Recent biomechanical studies on beagles with<jats:italic>ADAMTS10<\/jats:italic>\u00a0mutation demonstrated that the mutant dogs have mechanically weak posterior sclera. This weakness was associated with a reduced collagen density and a lower proportion of insoluble collagen. These changes, observed before glaucoma development, were considered intrinsic characteristics caused by the mutation rather than a secondary effect of IOP elevation. Further studies of ADAMTS10\u2010OAG may elucidate the effects of altered biomechanical properties of ONH and PPS in determining the glaucoma progression.<\/jats:p>","DOI":"10.1111\/vop.12923","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T12:35:17Z","timestamp":1629203717000},"page":"316-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Biomechanics of the optic nerve head and sclera in canine glaucoma: A brief review"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-2760","authenticated-orcid":false,"given":"Shin Ae","family":"Park","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine Purdue University West Lafayette Indiana 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