{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:42:23Z","timestamp":1784630543592,"version":"3.55.0"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To document the effectiveness and outcome of corneal grafting using acellular porcine corneal stroma (APCS) for veterinary use (BioCorneaVet<jats:sup>\u2122<\/jats:sup>) to restore corneal integrity in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A review of medical records of patients that underwent keratoplasty with APCS graft to repair deep corneal defects, descemetoceles, and perforations between 2019 and 2021 was carried out. Only animals with intact dazzle reflex, consensual PLR before the surgery and a minimum follow\u2010up of four weeks were considered for the study, with forty dogs (1 eye each) meeting the inclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Brachycephalic breeds were the most frequently represented, and 20 right eyes and 20\u00a0left eyes were affected with 25 perforations, 8 descemetoceles, and 9 deep stromal defects (1 eye had both perforation and descemetocele). Most of the patients had concurrent ocular diseases or had undergone previous surgery on the other eye. Two different thickness of xenograft was used (300 or 450\u00a0\u00b5m), and the diameter ranged from 3 to 10\u00a0mm. Postoperative complications included mild to severe corneal vascularization, partial dehiscence, melting, and glaucoma. Follow\u2010up time ranged from 28 to 797\u00a0days (mean: 233\u00a0days). Ocular integrity was maintained in 37\/40 cases (92.5%), and vision was preserved in 36 cases (90%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of APCS (BioCorneaVet<jats:sup>\u2122<\/jats:sup>) is an effective surgical treatment for deep stromal defects, descemetocele, and perforations in dogs, providing a good tectonic support and preserving anatomical integrity and vision. The cosmetic appearance was considered good in all the cases and continued to improve with time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12927","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T06:53:25Z","timestamp":1630738405000},"page":"469-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The use of acellular porcine corneal stroma xenograft (BioCorneaVet<sup>\u2122<\/sup>) for the treatment of deep stromal and full thickness corneal defects: A retrospective study of 40 cases (2019\u20132021)"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-2221","authenticated-orcid":false,"given":"Daniele","family":"Santillo","sequence":"first","affiliation":[{"name":"Eye Vet Referral Sutton Weaver Cheshire UK"},{"name":"Centro Veterinario Specialistico Roma 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