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Testing to investigate the presence of potential infectious diseases included a complete blood count, biochemistry, protein electrophoresis, West Nile virus (WNV) plaque reduction neutralization test,<jats:italic>Toxoplasma gondii<\/jats:italic>modified direct agglutination test, WNV RT\u2010PCR, and Avian Influenza RT\u2010PCR. A necropsy was performed on all owls, including ocular histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fundus lesions included retinal detachment (7\/15 owls), depigmented lesions (12\/15), pigment clumping (8\/15), and retinal tear (4\/15). All birds were negative for WNV and Avian Influenza on RT\u2010PCR. Of the owls with chorioretinitis, 3\/15 were seropositive for WNV and 7\/15 for<jats:italic>T<\/jats:italic>.\u00a0<jats:italic>gondii<\/jats:italic>. Optical coherence tomography of 25\/30 affected eyes revealed outer retinal lesions (19\/25 eyes), retinal detachment (16\/25), and retinal tears (3\/25). Histopathological examination revealed outer nuclear layer atrophy (19\/30 eyes), retinal detachment (18\/30), retinal tears (7\/30), suprachoroidal hemorrhage (12\/30), scleral rupture (3\/30), and ossicle fracture (3\/30).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although 20% of birds were seropositive for WNV and 46.6% for<jats:italic>T<\/jats:italic>.\u00a0<jats:italic>gondii<\/jats:italic>, histopathologic findings supported that the posterior segment lesions in the study group were likely due to blunt ocular trauma rather than an infectious etiology. The results of OCT imaging and histopathology documented retinal changes most consistent with blunt ocular trauma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12942","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T06:55:51Z","timestamp":1632984951000},"page":"128-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical and pathologic evaluation of chorioretinal lesions in wild owl species"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8993-180X","authenticated-orcid":false,"given":"Alessandra V.","family":"Keenan","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Oster","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-0883","authenticated-orcid":false,"suffix":"Jr.","given":"Richard J.","family":"McMullen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine Auburn University Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian\u00a0C.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin School of Veterinary Medicine University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0977-7364","authenticated-orcid":false,"given":"Richard R.","family":"Dubielzig","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin School of Veterinary Medicine University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9960-678X","authenticated-orcid":false,"given":"Leandro B. 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