{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:43:46Z","timestamp":1766580226219,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to determine the effects and potential side effects of topical preservative\u2010free (PF) tafluprost 0.0015% in ophthalmologically normal horses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Five adult grade horses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>One of the eyes of each horse was randomly chosen as the \u201ctreatment\u201d eye, and consequently, the contralateral eye served as the \u201ccontrol.\u201d A single dose of PF tafluprost 0.0015% (0.2\u00a0mL) was instilled in the treated eye of each horse. Intraocular pressure (IOP), Schirmer's tear test (STT) levels of each eye, and an ophthalmic examination were performed at T0 (baseline), T30, T120, T24\u00a0h, and T48\u00a0h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean IOP values of the treated eyes at baseline (T0), T30, T120, T24\u00a0h, and T48\u00a0h were 25.4\u00a0\u00b1\u00a04.8\u00a0mmHg, 21.2\u00a0\u00b1\u00a01.92\u00a0mmHg, 15.20\u00a0\u00b1\u00a02.48\u00a0mmHg, 18.40\u00a0\u00b1\u00a01.51\u00a0mmHg, and 24.60\u00a0\u00b1\u00a01.94\u00a0mmHg, respectively. Significant differences were observed between the mean baseline IOP level and the T120 and T24\u00a0h time points (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.009). The mean STT levels at each time point showed insignificant fluctuations during the study (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.140). Adverse effects such as chemosis and episcleral injection were observed 30\u00a0min after the instillation of tafluprost 0.0015% (T30). Blepharospasm and conjunctival hyperemia were observed 120\u00a0min (T120) after the administration of the medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical relevance<\/jats:title><jats:p>Tafluprost 0.0015% showed potential in reducing IOP, but due to its local side effects, it is not a good candidate for management of glaucoma in horses. Tafluprost did not notably affect STT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12957","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T13:21:40Z","timestamp":1637587300000},"page":"173-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of 0.0015% preservative\u2010free tafluprost on the equine eye"],"prefix":"10.1111","volume":"25","author":[{"given":"Saeed","family":"Azimpour","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, Babol Branch Islamic Azad University  Babol Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Emami alagha","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Islamic Azad University, Karaj Branch  Alborz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houman","family":"Faghihi","sequence":"additional","affiliation":[{"name":"Ophthalmology Section Negah Veterinary Centre  Tehran Iran"},{"name":"Department of Clinical Sciences Faculty of Veterinary Specialized Sciences Islamic Azad University, Science and Research Branch  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-8025","authenticated-orcid":false,"given":"Seyed\u00a0Mehdi","family":"Rajaei","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Islamic Azad University, Karaj Branch  Alborz Iran"},{"name":"Ophthalmology Section Negah Veterinary Centre  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Shokoohimand","sequence":"additional","affiliation":[{"name":"Ophthalmology Section Negah Veterinary Centre  Tehran Iran"},{"name":"Department of Clinical Sciences Faculty of Veterinary Specialized Sciences Islamic Azad University, Science and Research Branch  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2017.07.005"},{"key":"e_1_2_6_3_1","first-page":"1841","volume-title":"Veterinary Ophthalmology","author":"Plummer CE","year":"2021"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12370"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2011.00914.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20103306.2010.tb05637.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2015.06.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20103292.2011.00310.x"},{"key":"e_1_2_6_9_1","first-page":"453","volume-title":"Equine Ophthalmology","author":"Wilkie DA","year":"2017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1945"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102012\u2010303026"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2003.12.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12341"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.5935\/0004\u20102749.20160010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2007.0065"},{"issue":"1","key":"e_1_2_6_16_1","first-page":"72","article-title":"Effect of topical ophthalmic latanoprost on intraocular pressure in normal horses","volume":"3","author":"Davidson HJ","year":"2002","journal-title":"Vet Ther Spring"},{"key":"e_1_2_6_17_1","unstructured":"FDA.Latanoprost ophthalmic solution. 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