{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:29Z","timestamp":1747188449234,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001116","name":"Foundation Fighting Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe a case of monocular retinopathy of prematurity (ROP)\u2010like vasculopathy without oxygen supplementation in the dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fundus photographs (RetCam), spectral\u2010domain optical coherence tomography (sdOCT), confocal scanning laser ophthalmoscopy (cSLO), and fluorescein angiography (FA), as well as postmortem histology and immunohistochemistry (Collagen IV and anti\u2010vWF antibodies), were carried out to characterize the vascular abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ophthalmic examination showed peripheral and mid\u2010temporal avascular areas in the tapetal region, neovascularization and abnormally dilated and tortuous retinal vessels in the left eye. sdOCT demonstrated not only cross\u2010sectional views of preretinal fibrovascular proliferation but also extensive proliferation extraretinally into the vitreous. FA emphasized demarcation of vascular and avascular zones with neovascular tufts \u201cpopcorns.\u201d Histology and immunohistochemistry confirmed presence of abnormally dilated vessels and the intravitreal blood vessels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ROP is a disease of abnormally developed retinal vascularization associated with oxygen supplementation therapy, potentially causing blindness in premature infants. Although the mechanism of ROP\u2010like vasculopathy in our case is unclear, it is important to appreciate that the abnormal vascular pattern seen in ROP in premature infants can occur in canines without oxygen administration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12959","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T17:57:35Z","timestamp":1638554255000},"page":"78-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monocular retinopathy of prematurity\u2010like retinal vasculopathy in a dog"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-1349","authenticated-orcid":false,"given":"Yu","family":"Sato","sequence":"first","affiliation":[{"name":"Section of Ophthalmology and Division of Experimental Retinal Therapies Department of Clinical Sciences and Advanced Medicine School of Veterinary Medicine University of Pennsylvania 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-1641","authenticated-orcid":false,"given":"Valerie","family":"Dufour","sequence":"additional","affiliation":[{"name":"Section of Ophthalmology and Division of Experimental Retinal Therapies Department of Clinical Sciences and Advanced Medicine School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Lutty","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9324-0155","authenticated-orcid":false,"given":"Keiko","family":"Miyadera","sequence":"additional","affiliation":[{"name":"Section of Ophthalmology and Division of Experimental Retinal Therapies Department of Clinical Sciences and Advanced 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