{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:05:26Z","timestamp":1779199526550,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the outcomes of canine patients diagnosed with corneal ulceration associated with presumed calcareous corneal degeneration (CCD) that were treated with diamond burr keratotomy (DBK) and ongoing postoperative topical 3% or 4% Ethylenediaminetetraacetic acid\u00a0(EDTA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Retrospective assessment of CCD cases treated with ongoing topical EDTA following DBK between 2011 and 2020 at Veterinary Ophthalmic Referrals. Descriptive statistics of the study population were assessed, and a survival analysis was performed using R statistical software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 51 eyes from 41 dogs were assessed, with small terrier breeds overrepresented (27\/41, 65.9%). Median age of dogs at the time of diagnosis was 14.3\u00a0years (range 8\u201317.2\u00a0years). Following DBK, the median time to commencement of topical EDTA was 11\u00a0days (range 0\u201328\u00a0days). Cases were followed for a median duration of 216\u00a0days (range 42\u20131379\u00a0days). Corneal ulceration recurred in 7\/51 (13.7%) eyes at a median duration of 80\u00a0days (range 63\u2013156\u00a0days). The probability of recurrence of corneal ulceration associated with CCD at 12\u00a0months was 15.6% (95% CI: 4.1\u201325.7%). A second DBK procedure followed by ongoing topical EDTA was performed in 4\/7 (57.1%) of the recurred eyes. These retreated eyes had no further recurrence recorded and a median follow\u2010up time of 401\u00a0days (range 120\u2013858\u00a0days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ongoing topical EDTA following DBK is an effective adjunct treatment method for CCD with reduced rates of recurrence of CCD\u2010associated corneal ulceration when compared to published rates of recurrence when treated with DBK alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12969","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T11:55:38Z","timestamp":1641815738000},"page":"225-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Topical Ethylenediaminetetraacetic acid (EDTA) administration following corneal diamond burr keratotomy for calcareous corneal degeneration in canines"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-7005","authenticated-orcid":false,"given":"Zoe","family":"Anastassiadis","sequence":"first","affiliation":[{"name":"Veterinary Ophthalmic Referrals  Plympton Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Read","sequence":"additional","affiliation":[{"name":"Veterinary Ophthalmic Referrals  Plympton Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-213X","authenticated-orcid":false,"given":"Kellam D.","family":"Bayley","sequence":"additional","affiliation":[{"name":"Pet Eye Care  Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1082","volume-title":"Veterinary Ophthalmology","author":"Whitley 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