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The development of optical coherence tomography angiography (OCT\u2010A) allows a non\u2010invasive detailed examination of posterior segment vasculature. The purpose of this prospective study was to compare imaging of posterior segment vasculature in normal dogs and cats using OCT\u2010A, fluorescein angiography (FA), and indocyanine green angiography (ICGA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight adult funduscopically normal dogs and 13 funduscopically normal cats were included in the study. Retinal vasculature was assessed by OCT\u2010A followed by ICGA then FA. Regular fundus imaging was also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High\u2010resolution images of the different vascular layers within the retina and choroid could be acquired using OCT\u2010A in both dogs and cats. The technique provided more detail than obtained with FA\/ICGA. However, artifacts\/errors can occur during OCT\u2010A image acquisition\/analysis\/interpretation and must be considered. Furthermore, OCT\u2010A only allows for a limited field of view compared to FA\/ICGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Optical coherence tomography angiography is a new non\u2010invasive posterior segment imaging technique that is complementary to traditional dye\u2010based angiographic techniques. Detailed imaging of the dog and cat posterior segment can be achieved under general anesthesia. OCT\u2010A provides additional detail of the vasculature and can clearly demonstrate the anatomical depth of the imaged vessels. There are, however, some limitations to this new technique that may be overcome by future technological advances.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12973","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T12:55:11Z","timestamp":1644843311000},"page":"164-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Non\u2010invasive optical coherence tomography angiography: A comparison with fluorescein and indocyanine green angiography in normal adult dogs and cats"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1568-4527","authenticated-orcid":false,"given":"Laurence M.","family":"Occelli","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris 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