{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:18:10Z","timestamp":1773015490795,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the relationship between Minimum Inhibitory Concentration (MICs) and response to therapy of 6<jats:italic>Fusarium<\/jats:italic>spp<jats:italic>.<\/jats:italic>and 5<jats:italic>Aspergillus fumigatus<\/jats:italic>isolated from equine ulcerative keratitis cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Fungi were identified by morphology and Internal Transcribed Spacer (ITS) polymerase chain reaction (PCR) with sequencing and evaluated at the University of Texas Fungal Testing Laboratory for susceptibility to three azole antifungals (miconazole, voriconazole, posaconazole), natamycin, and two echinocandins (anidulafungin, caspofungin). A Mann\u2013Whitney rank sum test was used for the comparison of time to heal between infections of different fungal genera and in vitro susceptibility to the drug administered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Fusarium<\/jats:italic>spp. were resistant to azole antifungals in 6\/6 cases (100%).<jats:italic>Fusarium<\/jats:italic>spp. were susceptible to echinocandins and natamycin in all cases.<jats:italic>A.\u00a0fumigatus<\/jats:italic>was resistant to anidulafungin in 1\/5 cases (20%) and posaconazole in 1\/5 cases (20%) The remainder of<jats:italic>A.\u00a0fumigatus<\/jats:italic>isolates were susceptible to all antifungal agents tested.<jats:italic>Fusarium<\/jats:italic>isolates were treated with antifungals to which they were not susceptible; however, all cases of<jats:italic>A.\u00a0fumigatus<\/jats:italic>were treated with antifungals to which they were susceptible. All<jats:italic>Fusarium<\/jats:italic>cases and<jats:italic>A.\u00a0fumigatus<\/jats:italic>cases experienced clinical resolution, regardless of surgical intervention. There was no statistical correlation between fungal genus and time to heal (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.082).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The in vitro susceptibility indicated that all cases of<jats:italic>Fusarium<\/jats:italic>spp. were resistant to azole antifungal drugs which were used as treatment. Clinical outcomes, however, showed that all cases healed despite resistance to antifungals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12995","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T05:30:11Z","timestamp":1654839011000},"page":"376-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["In vitro antifungal susceptibility of<i>Fusarium<\/i>species and<i>Aspergillus fumigatus<\/i>cultured from eleven horses with fungal keratitis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3566-4398","authenticated-orcid":false,"given":"Paoul S.","family":"Martinez","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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