{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:11:29Z","timestamp":1784243489762,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe the complications of conjunctival graft surgery occurring in cases at a referral ophthalmic service and evaluate factors that lead to occurrence of complications in canine cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case\u2013control study was completed using data from the Veterinary Medical Center at the Western College of Veterinary Medicine, Saskatoon, Canada, between May 2015 and March 2020. Case records from dogs that underwent conjunctival pedicle graft surgery and subsequently either did or did not develop a conjunctival graft complication were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and six dogs undergoing conjunctival graft surgeries were identified. Sixteen conjunctival graft complications occurred, of which, eight led to negative outcomes. Univariable analysis comparing canine eyes that developed complications to control eyes revealed potential (<jats:italic>p<\/jats:italic>\u2009\u2264\u2009.05) differences between the groups in post\u2010operative fluoroquinolone use,<jats:italic>Streptococcus canis<\/jats:italic>isolation, intraoperative intravenous cefazolin use, corneal stromal white cell infiltrate, and mean ulcer diameter. The use of intraoperative cefazolin could not be effectively evaluated with available data; however, no dogs (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) receiving intraoperative cefazolin developed complications. Multivariable analysis revealed that dogs that were treated with a second\u2010generation fluoroquinolone and that had<jats:italic>S.\u00a0canis<\/jats:italic>isolated had higher odds of experiencing complications than dogs that were not treated with a second\u2010generation fluoroquinolone and that were<jats:italic>S.\u00a0canis<\/jats:italic>negative (Odds ratio\u00a0=\u00a064.7 [95% CI 6.3\u2013669],<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Streptococcus<\/jats:italic>species played a role in conjunctival graft complications in our study. Empiric selection of second\u2010generation fluoroquinolone monotherapy may need reconsideration given the frequent isolation of<jats:italic>Streptococcus<\/jats:italic>spp. from canine ulcers. The use of intraoperative cefazolin may be associated with a lower complication rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13008","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T07:08:28Z","timestamp":1656313708000},"page":"53-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of conjunctival graft procedures and factors that lead to graft complications in canine cases"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0933-291X","authenticated-orcid":false,"given":"Stephanie C.","family":"Osinchuk","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine University of Saskatchewan Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2252-2243","authenticated-orcid":false,"given":"Shayna","family":"Levitt","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5852-9308","authenticated-orcid":false,"given":"Lynne Sheila","family":"Sandmeyer","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine University of Saskatchewan Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-8790","authenticated-orcid":false,"given":"Sarah E.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine University of Saskatchewan Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"44","article-title":"Conjunctival flap operation","volume":"116","author":"Stern AI","year":"1950","journal-title":"JAVMA"},{"key":"e_1_2_7_3_1","first-page":"387","article-title":"Tarsoconjunctival pedicle grafts for deep corneal ulceration in the dog and cat","volume":"13","author":"Peiffer RL","year":"1977","journal-title":"J Am Hosp Assoc"},{"key":"e_1_2_7_4_1","first-page":"641","article-title":"Conjunctival pedicle grafting in the treatment of corneal ulcers in the dog and cat","volume":"23","author":"Hakanson NE","year":"1987","journal-title":"J Am Hosp Assoc"},{"key":"e_1_2_7_5_1","first-page":"602","article-title":"Further comments on conjunctival pedicle grafting in the treatment of corneal ulcers in the dog and cat","volume":"24","author":"Hakanson 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