{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:05:06Z","timestamp":1773417906032,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the clinical history, surgical management, and histologic findings of meibomian gland calcification and osseous metaplasia in a horse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Studied<\/jats:title><jats:p>A 21\u2010year\u2010old Selle Fran\u00e7ais gelding presented with a 9\u00a0months history of blepharitis, blepharospasm, and epiphora affecting the right eye. The horse was diagnosed with meibomianitis and impaction with associated granulomas, but not treated surgically for 6\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Physical and ophthalmic examinations, and systemic bloodwork were performed. A diamond burr debridement was performed on a corneal ulceration, and meibomian gland nodules were excised and examined histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple firm concretions were associated with the palpebral conjunctiva of each eyelid. The largest nodule (5\u2009\u00d7\u20094\u2009\u00d7\u200910\u2009mm) was excised from the lower right eyelid. Histology revealed dilated meibomian ducts with mineralized inspissated secretions surrounded by fibrosis and osseous metaplasia. Following nodule excision and corneal ulcer resolution, no blepharospasm or epiphora recurred for a follow\u2010up period of 15\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Calcification and osseous metaplasia of the meibomian glands was identified in a Selle Fran\u00e7ais gelding. It is suspected that inspissated meibomian secretions led to a local granulomatous reaction with secondary dystrophic calcification and osseous metaplasia<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13011","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T09:35:46Z","timestamp":1658396146000},"page":"163-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Calcification and osseous metaplasia of the meibomian glands of a horse"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-8543","authenticated-orcid":false,"given":"Kerry","family":"Gunsalus","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The Veterinary Medical Center of Long Island  West Islip New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Taylor","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin School of Veterinary Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelle La","family":"Croix","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Veterinary Medical Center of Long Island  West Islip New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"197","volume-title":"Equine Ophthalmology","author":"Giuliano EA","year":"2017"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30438-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228822"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12645"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(96)80064-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci7020037"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2000.3230087.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.978"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2010.00214.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12412"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119047919.ch7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2010.12.002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997b"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12864"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.250.1.78"},{"key":"e_1_2_6_17_1","article-title":"Persistent hypercalcemia and hyperparathyroidism in a horse","volume":"2014","author":"Villagr\u00e1n CC","year":"2014","journal-title":"Case Rep Vet Med"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.104265"},{"key":"e_1_2_6_19_1","first-page":"1","volume-title":"Pathological Basis of Veterinary Disease","author":"Myers RK","year":"2007"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.13011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T19:34:20Z","timestamp":1692732860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":18,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/vop.13011"],"URL":"https:\/\/doi.org\/10.1111\/vop.13011","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,21]]},"assertion":[{"value":"2021-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}