{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:41Z","timestamp":1747188461849,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the corneal toxicity of erlotinib in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal studied<\/jats:title><jats:p>A 13\u2010year\u2010old castrated male Maltese dog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A dog\u00a0with lung cancer presented with a month\u2010long history of mucoid discharge and blepharospasm in both eyes. Corneal ulcerations with stromal thinning were diagnosed in both eyes, which were refractory after 2\u2009weeks of treatment with topical antibiotics and artificial tears. The dog was orally administered erlotinib (Tarceva\u00ae) by his owner for 2\u2009months to treat his lung cancer. Urgent withholding of erlotinib was recommended, and after 2\u2009weeks of discontinuation, the corneal defects resolved; however, corneal thinning remained until the six\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To the best of author's knowledge, this is the first report in the veterinary literature that describes bilateral corneal ulcers associated with erlotinib administration in a dog.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13034","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T14:05:23Z","timestamp":1666793123000},"page":"78-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Presumed <scp>erlotinib\u2010induced<\/scp> bilateral corneal ulcers in a dog with lung tumor"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-9149","authenticated-orcid":false,"given":"Sunjun","family":"Jung","sequence":"first","affiliation":[{"name":"Allimals Animal Medical Center  Jeonju Korea"},{"name":"College of Veterinary Medicine Jeonbuk National University  Iksan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31818fdbc6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514696"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001808"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.12.025"},{"key":"e_1_2_5_6_1","first-page":"379132","article-title":"Perforating corneal ulceration in a patient with lung metastatic adenocarcinoma treated with gefitinib: a case report","volume":"2012","author":"Ibrahim E","year":"2012","journal-title":"Case Rep Ophthalmol Med"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.15446\/rcciquifa.v49n2.89898"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.13.3267"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701630"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2000.0979"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318166f483"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.03.002"},{"issue":"12","key":"e_1_2_5_13_1","first-page":"3859","article-title":"Ocular surface adverse events of systemic inhibitors of the epidermal growth factor receptor (EGFRi): a prospective trial","volume":"57","author":"Saint\u2010Jean A","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.13034","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T10:09:30Z","timestamp":1692526170000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/vop.13034"],"URL":"https:\/\/doi.org\/10.1111\/vop.13034","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"type":"print","value":"1463-5216"},{"type":"electronic","value":"1463-5224"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"2022-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}