{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:41:37Z","timestamp":1775238097247,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The exposure to constant light during the hospitalization was investigated to verify its influence on the daily rhythmicity of Schirmer tear test I (STT I) in the<jats:italic>Felis catus<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal studied<\/jats:title><jats:p>One group (HG\u2014hospitalized group) was consisted of 10 owned\u2010cats hospitalized to perform a sterilization procedure and was exposed to a 24\/0 light\/dark (L\/D) cycle; the cat control group (CG) was consisted of 10 staff\u2010owned cats living in an indoor environment (12\/12\u2009L\/D cycle).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The STT I values was performed at 4\u00a0h intervals over a 48\u2009h period (starting at 8:00\u2009a.m. on Day 1 and finishing at 8:00\u2009a.m. on Day 3) on the left (LE) and right (RE) eyes into two cat groups. A 35\u2009x\u20095\u2009mm commercial tear test strip was used to record tear production in millimeters wetting per minute (mm\/min).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate for repeated measure analysis of variance (ANOVA) showed a statistically significant effect of time. No difference was found between LE and RE tear production, and between the two experimental conditions. Robust daily rhythmicity was exhibited by the STT I in both eyes during the entire monitoring period in control cats and only during the Day 1 in hospitalized cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data are a starting point for evaluating the imbalance of ocular physiology observed in hospitalized cats. Further studies on larger sample size and exposing the animals to various hospitalization procedures are needed to establish whether these alterations are caused by hospitalization procedures or by the light\/dark schedules.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13037","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T05:48:23Z","timestamp":1667800103000},"page":"119-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hospitalization disrupts the daily rhythm of tear production in cats"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-0833","authenticated-orcid":false,"given":"Simona","family":"Di Pietro","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences University of Messina, Polo Universitario dell'Annunziata Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Tabb\u00ec","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Messina, Polo Universitario dell'Annunziata Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annastella","family":"Falcone","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Messina, Polo Universitario dell'Annunziata Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Macr\u00ec","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Messina, Polo Universitario dell'Annunziata Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Piccione","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Messina, Polo Universitario dell'Annunziata Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Giudice","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Messina, Polo Universitario dell'Annunziata Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3049-1181","authenticated-orcid":false,"given":"Claudia","family":"Giannetto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Messina, Polo Universitario dell'Annunziata Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-34-1-79"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.1422"},{"key":"e_1_2_6_4_1","first-page":"125","volume-title":"Veterinary Ophthalmology","author":"Gum GG","year":"1991"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10050820"},{"key":"e_1_2_6_6_1","first-page":"424","article-title":"Evaluation of ocular toxicity of two beta blocking drugs, carteolol and practolol, in beagle dogs","volume":"224","author":"Tanaka N","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_7_1","first-page":"376","article-title":"Keratoconjunctivitis sicca: immunological evaluation of 62 canine cases","volume":"46","author":"Kaswan RL","year":"1985","journal-title":"Am J Vet Res"},{"key":"e_1_2_6_8_1","first-page":"924","article-title":"Sulfonamide\u2010associated keratoconjunctivitis sicca and corneal ulceration in a dysuric dog","volume":"89","author":"Collins BK","year":"1986","journal-title":"J Am Vet Assoc"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.2460\/javma.1992.200.10.1481","article-title":"Effect of topically administered atropine on tear production in dogs","volume":"200","author":"Hollingsworth SR","year":"1992","journal-title":"J Am Vet Assoc"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2005.05.017"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.21.03.0114"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1985.tb02092.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.580414"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X17733207"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.104974"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2003.00302.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2005.00437.x"},{"key":"e_1_2_6_18_1","volume-title":"Circadian Physiology","author":"Refinetti R","year":"2006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1987.95"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00647.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00717.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12673"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jveb.2012.09.004"},{"key":"e_1_2_6_24_1","first-page":"214","article-title":"Effect of atropine sulfate on tear production in the cat when used with ketamine hydrochloride and acetylpromazine maleate","volume":"185","author":"Arnett BD","year":"1984","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00738.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2003.00313.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.77.3.310"},{"key":"e_1_2_6_28_1","first-page":"75","article-title":"Postanaesthetic tear production and ocular irritation in cats","volume":"43","author":"Peche N","year":"2015","journal-title":"Tier\u00e4rztl Prax"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.4314\/ovj.v10i1.10"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2008.10.004"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jveb.2012.09.004"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/09291016.2012.756254"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jveb.2016.02.002"},{"key":"e_1_2_6_34_1","first-page":"274","article-title":"Preliminary evaluation of tear production in dogs hospitalized in an intensive care unit","volume":"23","author":"Chandler JA","year":"2013","journal-title":"JVECC"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.04.003"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.256.6.681"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.59.215"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.13037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T11:00:39Z","timestamp":1728298839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,6]]},"references-count":36,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/vop.13037"],"URL":"https:\/\/doi.org\/10.1111\/vop.13037","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,6]]},"assertion":[{"value":"2022-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}