{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:55:40Z","timestamp":1791280540391,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report a case of idiopathic lipid keratopathy in a normolipemic cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Studied<\/jats:title><jats:p>A 10\u2010year\u2010old neutered female European domestic cat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A cat was evaluated for bilateral white corneal deposits. Slit\u2010lamp examination revealed multiple, well\u2010defined, round, stromal, cream\u2010colored deposits of different sizes associated with generalized superficial corneal vascularization. Blood lipids were normal, and no history of travel to tropical locations or ocular trauma was present. Topical betamethasone\/gentamicin 0.1% suspension q 12 hours did not result in any improvement of clinical appearance after one week. Tomography following the initial therapy revealed dense, hyperreflective deposits with posterior shadowing in the anterior and mid stroma of both corneas. A four\u2010week course of itraconazole 0.01% ophthalmic cream was prescribed q 12 hours with no improvement. Four months after the initial examination, a diagnostic superficial keratectomy and amniotic membrane implantation were performed. Histopathological analysis showed membrane bound vacuoles with infiltration of foamy macrophages suggesting a diagnosis of primary lipidosis. The post\u2010surgical period was unremarkable, and ten days later, the patient was re\u2010examined. Opacification from a corneal leukoma was observed in the excision site with mild fibrotic tissue. Two months post\u2010keratectomy, no further changes were detected in the cornea, and the patient was managed only with topical lubricant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this is the first report of idiopathic corneal lipidosis in a cat and may be considered as a differential diagnosis of corneal disease in felines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13038","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T14:07:25Z","timestamp":1668607645000},"page":"71-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disseminated idiopathic lipid keratopathy in a normolipemic cat"],"prefix":"10.1111","volume":"26","author":[{"given":"Andr\u00e9s","family":"Botello\u2010B\u00e1rcenas","sequence":"first","affiliation":[{"name":"Veterinaria Oftalvet  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-5222","authenticated-orcid":false,"given":"Rodrigo","family":"Garc\u00eda\u2010Santisteban","sequence":"additional","affiliation":[{"name":"Veterinaria Oftalvet  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abelardo","family":"Rodriguez\u2010Reyes","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Para Evitar la Ceguera en M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Brookseyes LLC  Alachua Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Adolfo","family":"Garc\u00eda\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Veterinaria Oftalvet  Mexico City 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