{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:02:36Z","timestamp":1791054156454,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We hypothesized that keratouveitis still occurs despite current widespread use of Canine adenovirus (CAV)\u20102 vaccinations and assessed the utility of CAV\u20101 and CAV\u20102 titers in elucidation of its etiopathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>Nine dogs with unexplained keratouveitis (14 eyes) and nine control dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>The Animal Health Trust clinical database was searched between 2008 and 2018 to identify cases of keratouveitis. Inclusion criteria included known vaccination status, interval from vaccination to development of clinical signs and availability of CAV titers. Cases were excluded if they were older than 1\u2009year of age, or other causative ocular pathology for corneal edema was identified. Nine age\u2010matched dogs without corneal edema but with CAV titers were included as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean CAV\u20101 and CAV\u20102 titers were not statistically different between dogs with keratouveitis and controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.16 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.76, respectively). Three cases had CAV\u20101 titers &gt;5000 and two of these cases had rising convalescence titers (greater than an 11\u2010fold increase) suggesting infection with wild\u2010type CAV\u20101. The six other cases did not appear to be associated with CAV infection or vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Keratouveitis continues to occur despite the advent of CAV\u20102 vaccinations. While this study found no evidence to indicate CAV\u20102 vaccination causes keratouveitis, the data indicates that in a proportion of cases, contemporaneous wild\u2010type CAV\u20101 infection is a possible cause.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13085","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T09:59:49Z","timestamp":1680256789000},"page":"262-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Keratouveitis in juvenile dogs and its presumed association with canine adenovirus infection"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-308X","authenticated-orcid":false,"given":"Hannah","family":"Joyce","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Centre for Small Animal Studies Animal Health Trust  Newmarket UK"},{"name":"Department of Ophthalmology, Dick White Referrals Part of Linnaeus Veterinary Limited  Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A. C.","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre for Small Animal Studies Animal Health Trust  Newmarket UK"},{"name":"Department of Ophthalmology, Dick White Referrals Part of Linnaeus Veterinary Limited  Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Fricker","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dick White Referrals Part of Linnaeus Veterinary Limited  Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willie","family":"Weir","sequence":"additional","affiliation":[{"name":"School of Biodiversity, One Health and Veterinary Medicine University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Fleming","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre for Small Animal Studies Animal Health Trust  Newmarket UK"},{"name":"Department of Ophthalmology, Dick White Referrals Part of Linnaeus Veterinary Limited  Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"69","volume-title":"An Acute Virus Disease with Liver Lesion in Dogs (Hepatitis Contagiosa Canis): A Pathologico\u2010Anatomical and Etiological Investigation","author":"Rubarth S","year":"1947"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.112.15.347"},{"issue":"11","key":"e_1_2_6_4_1","first-page":"1778","article-title":"Cross\u2010protective immunity to canine adenovirus type 2 by canine adenovirus type 1 vaccination","volume":"39","author":"Emery JB","year":"1978","journal-title":"Am J Vet Res"},{"key":"e_1_2_6_5_1","unstructured":"CabassoVJ.Infectious canine hepatitis [virus foxes dogs and skunks].Infectious Diseases of Wild Mammals.1981. 191(4). Accessed January 19 2022.https:\/\/agris.fao.org\/agris\u2010search\/search.do?recordID=US19830856904"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","unstructured":"SykesJE.Infectious canine hepatitis.Canine and Feline Infectious Diseases.2014. 182(4).","DOI":"10.1016\/B978-1-4377-0795-3.00018-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1988.tb03512.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.2_12431"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.154.15.457"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13020183"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4167\/jbv.2018.48.3.102"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2002.00217.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2003.00025.x"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T06:49:04Z","timestamp":1692514144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/vop.13085"],"URL":"https:\/\/doi.org\/10.1111\/vop.13085","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,31]]},"assertion":[{"value":"2022-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}