{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:52Z","timestamp":1747188472180,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spontaneous intraocular tumors are rarely reported in rabbits, despite their widespread use as laboratory animals. We describe two cases of intraocular neuroectodermal embryonal tumors, formerly primitive neuroectodermal tumors, in young rabbits. Histologically, both tumors exhibited prominent rosette or pseudorosettes, consistent with the histomorphology seen in human tumors. The neuroectodermal subtype is supported by immunoreactivity for the neuronal markers, SRY\u2010box transcription factor 2, microtubule\u2010associated protein 2, neuronal nuclear protein, and neuron\u2010specific enolase. In one of the rabbits, there was metastasis to the contralateral conjunctiva. Intraocular neoplasms can occur in young rabbits and eyes with refractory disease should be enucleated for clinical management.<\/jats:p>","DOI":"10.1111\/vop.13095","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T11:09:02Z","timestamp":1680520142000},"page":"250-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intraocular neuroectodermal embryonal tumor in two rabbits"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0532-8369","authenticated-orcid":false,"given":"Carmon","family":"Co","sequence":"first","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College University of Guelph  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Brakel","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin, Department of Pathobiological Science, School of Veterinary Medicine University of Wisconsin Madison  Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantale L.","family":"Pinard","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College University of Guelph  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870601800517"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-8478cr20200001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2005.04043.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2012.01067.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12062"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638721994601"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2004.04054.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12056"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.24070\/bjvp.1983-0246.v14i2p102-106"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/03009858211002190"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.26717\/bjstr.2020.26.004368"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","unstructured":"GrahnB PeifferR WilcockB.Histologic basis of ocular disease in animals.2018. doi:10.1002\/9781119108603","DOI":"10.1002\/9781119108603"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24213"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00567.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2005.00407.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlw042"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01695-w"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.015"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T06:48:47Z","timestamp":1692514127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/vop.13095"],"URL":"https:\/\/doi.org\/10.1111\/vop.13095","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"type":"print","value":"1463-5216"},{"type":"electronic","value":"1463-5224"}],"subject":[],"published":{"date-parts":[[2023,4,3]]},"assertion":[{"value":"2022-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}