{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:33:19Z","timestamp":1781541199550,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of 2% dorzolamide ophthalmic solution for reduction of postoperative ocular hypertension (POH) following routine phacoemulsification surgery in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals Studied<\/jats:title><jats:p>Thirty one dogs (53 eyes) with naturally occurring cataracts undergoing routine phacoemulsification surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure(s)<\/jats:title><jats:p>A prospective, double\u2010masked, randomized, placebo\u2010controlled study design was utilized. Dogs received 2% dorzolamide ophthalmic solution or saline 1\u2009h prior to surgery then three times daily for 21\u2009days postoperatively in the operated eye(s). Intraocular pressure (IOP) was recorded 1\u2009h prior to surgery and 3\u2009h, 7\u2009h, 22\u2009h, 1\u2009week and 3\u2009weeks postoperatively. Statistical analyses were performed using chi\u2010squared and Mann\u2013Whitney <jats:italic>U<\/jats:italic> test with a significance level of <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postoperative ocular hypertension (IOP\u2009\u226525\u2009mmHg, &lt;24\u2009h after surgery) occurred in 28\/53 (52.8%) eyes. There was significant reduction in the incidence of POH for eyes receiving dorzolamide (10\/26 (38.4%) eyes) versus eyes receiving placebo (18\/27 (66.7%) eyes) (<jats:italic>p<\/jats:italic>\u2009=\u2009.0384). Animals were followed for a median of 163\u2009days after surgery. Thirty\u2010seven (37\/53 (69.8%)) eyes were visual at final examination and 3\/53 (5.7%) globes were enucleated postoperatively. At last follow\u2010up, there was no difference in visual status (<jats:italic>p<\/jats:italic>\u2009=\u2009.9280), need for topical IOP lowering medication (<jats:italic>p<\/jats:italic>\u2009=\u2009.8319) or incidence of glaucoma (<jats:italic>p<\/jats:italic>\u2009=\u2009.5880) based on treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perioperative administration of topical 2% dorzolamide reduced the incidence of POH after phacoemulsification in the dogs studied. However, this was not associated with differences in visual outcome, incidence of glaucoma or need for IOP\u2010lowering medications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13109","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T13:03:40Z","timestamp":1683983020000},"page":"150-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of perioperative 2% dorzolamide ophthalmic solution for reduction of postoperative ocular hypertension in dogs following routine phacoemulsification surgery: A prospective clinical trial"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5671-3948","authenticated-orcid":false,"given":"Andrew C.","family":"Lewin","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University  Baton Rouge Louisiana 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