{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:57Z","timestamp":1747188477899,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To describe the clinical and histopathological features of ocular abnormalities noted in a litter of black\u2010footed ferrets (Mustela nigripes<\/jats:italic>), including corneal opacification, cataracts, persistent pupillary membranes, microphthalmia, symblepharon and anterior segment malformation.<\/jats:p><\/jats:sec>Animals Studied<\/jats:title>A litter of eight black\u2010footed ferrets examined at 10\u2009weeks old with a history of ophthalmia neonatorum first noted at 7\u2009days old and histopathological examination of three globes from three ferrets of the same litter between 5 and 7\u2009months old following routine subconjunctival enucleation.<\/jats:p><\/jats:sec>Procedures<\/jats:title>Due to the fractious nature of black\u2010footed ferrets, slit\u2010lamp biomicroscopic examination was performed under general isoflurane anesthesia at 10\u2009weeks of age. Corneal opacification was noted in 9\/16 eyes, cataracts in 4\/16 eyes, and persistent pupillary membranes in 3\/16 eyes, among other findings. Histopathology revealed persistent pupillary membranes and Descemet's membrane abnormalities consistent with congenital anterior segment malformation in all three globes. In one ferret, a posterior cortical cataract with posterior lenticular malformation and lens capsule discontinuity was noted. Purulent discharge was cultured at time of enucleation in one ferret with growth of E.\u2009coli<\/jats:italic>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A novel constellation of ocular malformations with primary congenital and secondary to ophthalmia neonatorum etiologies is described in black\u2010footed ferrets. Due to endangered status of black\u2010footed ferrets, small genetic pool and the requirement for adequate vision for wild\u2010release, congenital ocular abnormalities such as anterior segment malformation and likely the cataracts described are of particular concern. Further investigation and monitoring are warranted to determine the heritability of these ocular abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13146","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:59:57Z","timestamp":1694095197000},"page":"177-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Juvenile ocular abnormalities in a litter of black\u2010footed ferrets"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8762-7855","authenticated-orcid":false,"given":"Kore","family":"Chan","sequence":"first","affiliation":[{"name":"Hope Advanced Veterinary Center Vienna Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Climans","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin, Department of Pathobiological Sciences, School of Veterinary Medicine University of Wisconsin Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Helmick","sequence":"additional","affiliation":[{"name":"Smithsonian's Conservation Biology Institute Front Royal Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Della","family":"Garelle","sequence":"additional","affiliation":[{"name":"U.S. Fish and Wildlife Service National Black\u2010Footed Ferret Conservation Center Carr Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Adkins","sequence":"additional","affiliation":[{"name":"Hope Advanced Veterinary Center Vienna Virginia 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