{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:31:41Z","timestamp":1787506301503,"version":"build-2736575974"},"reference-count":83,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of the study was to identify bacterial pathogens and their antimicrobial sensitivity profile associated with cases of canine progressive ulcerative keratitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Analysis of microbial culture and sensitivity results from dogs with progressive ulcerative keratitis presenting to a UK referral practice between December 2018 and August 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Positive bacterial cultures were obtained from 80\/148 (54%) of the canine ulcers sampled with 99 bacterial isolates cultured.\n                      <jats:italic>Streptococcus canis<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929),\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919), and\n                      <jats:italic>Staphylococcus pseudintermedius<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916) were the most common isolates.\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      was more likely to be isolated whether the ulcer was clinically malacic at the time of sampling (OR\u2009=\u200910.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Ulcers treated prior to culture with fusidic acid were 7.6 times more likely to be positive than those treated with any other antimicrobial(s). Bacterial isolates demonstrated resistance against neomycin (85%), fusidic acid (78%), and tetracycline (68%). Conversely, isolates were most likely to be sensitive to gentamicin (88%), ofloxacin (77%), ciprofloxacin (73%), and chloramphenicol (64%). Antimicrobial combinations of chloramphenicol or gentamicin with a fluoroquinolone (ofloxacin or ciprofloxacin) or chloramphenicol combined with gentamicin were the most effective on in\u00a0vitro analysis (over 90% susceptibility of all isolates).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The most common bacterial species associated with canine progressive ulcerative keratitis in a UK referral population were\n                      <jats:italic>S. canis<\/jats:italic>\n                      ,\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      , and\n                      <jats:italic>S. pseudintermedius<\/jats:italic>\n                      . Combination antimicrobial therapy is recommended pending culture and sensitivity results given the varied antimicrobial susceptibility profiles and significant bacterial in\u00a0vitro resistance to antimicrobial monotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.13160","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:30:13Z","timestamp":1699345813000},"page":"330-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Progressive ulcerative keratitis in dogs in the United Kingdom: Microbial isolates, antimicrobial sensitivity, and resistance patterns"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8343-469X","authenticated-orcid":false,"given":"Robert","family":"Goss","sequence":"first","affiliation":[{"name":"Eye Veterinary Clinic  Herefordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki J.","family":"Adams","sequence":"additional","affiliation":[{"name":"Animal Cancer Trust  Suffolk UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Eye Veterinary Clinic  Herefordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Grundon","sequence":"additional","affiliation":[{"name":"Eye Veterinary Clinic  Herefordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Linn\u2010Pearl","sequence":"additional","affiliation":[{"name":"Eye Veterinary Clinic  Herefordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Scurrell","sequence":"additional","affiliation":[{"name":"Cytopath Ltd.  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