{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:08:02Z","timestamp":1747188482900,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T00:00:00Z","timestamp":1702080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the hyperproliferation of Elschnig pearl\u2010type posterior capsule opacification and concurrent uveitis in two canine eyes after phacoemulsification, followed by spontaneous resolution of the Elschnig pearls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Studied<\/jats:title><jats:p>A 10\u2010year\u2010old castrated male Spitz (Case 1) and a 4\u2010year\u2010old spayed female Bichon Frise (Case 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Elschnig pearls proliferating beyond the anterior capsulotomy site were observed in the right eye 10\u2009months after bilateral diabetic cataract surgery (Case 1) and 7\u2009months after unilateral cataract surgery (Case 2). In both cases, hyperproliferation occurred where the anterior capsule did not overlap with the intraocular lens (IOL), and was accompanied by aqueous flare. In Case 1, the pearls extended from the anterior capsule and adhered to the iris, causing focal posterior synechia. No other possible causes of uveitis were apparent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initially, uveitis severity improved after the administration of topical and systemic anti\u2010inflammatory drugs. However, uveitis recurred when the dosage of anti\u2010inflammatory treatment was reduced. The Elschnig pearls underwent morphological changes throughout the follow\u2010up period. In both cases, the pearls beyond the anterior capsulotomy resolved spontaneously after 5\u2009months. Only a few pearls remained between the IOL and posterior capsule, and no recurrence of pearl proliferation was observed at the last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To the best of our knowledge, this is the first report of spontaneous Elschnig pearl regression in dogs. Lens\u2010induced uveitis (LIU) may have been caused by anterior chamber hyperproliferative pearls. LIU associated with hyperproliferative pearls may be managed with appropriate anti\u2010inflammatory treatment and monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13173","type":"journal-article","created":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T06:09:41Z","timestamp":1702188581000},"page":"170-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperproliferation of Elschnig pearl\u2010type posterior capsule opacification and spontaneous regression in two pseudophakic canine eyes"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0313-7494","authenticated-orcid":false,"given":"Eunji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8759-5272","authenticated-orcid":false,"given":"Hyun\u2010ah","family":"Kim","sequence":"additional","affiliation":[{"name":"TIME Animal Medical Center  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6645-7116","authenticated-orcid":false,"given":"Kangmoon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8017-0891","authenticated-orcid":false,"given":"Seonmi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National 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