{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:05:46Z","timestamp":1777899946964,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<jats:bold>s<\/jats:bold><\/jats:title><jats:p>To identify canine breeds at risk for ocular melanosis and to compare the clinical and histologic features between affected Cairn Terriers (CTs) and non\u2010Cairn Terriers (NCTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Relative risk (RR) analysis and retrospective cohort study of dogs histologically diagnosed with ocular melanosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>The COPLOW archive was searched for globe submissions diagnosed with ocular melanosis. Six hundred fifty globes were included, and RR analysis was performed to identify at\u2010risk NCT breeds. A cohort of 360 CT and NCT globes diagnosed from 2013 to 2023 were included in the retrospective cohort study. Clinical data were collected from submission forms, medical records, and follow\u2010up surveys. One hundred fifty\u2010seven submissions underwent masked histologic review. Immunohistochemical staining for CD204 was performed to determine the predominance of melanophages in affected uvea from five NCTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At\u2010risk NCT breeds included the Boxer, Labrador Retriever, and French Bulldog. Glaucoma was the reported reason for enucleation in 79.4% of submissions. At enucleation, clinical features less prevalent in NCTs than CTs included pigmentary abnormalities in the contralateral eye (33.7% vs. 63.1%, <jats:italic>p<\/jats:italic>\u2009=\u2009.0008) and abnormal episcleral\/scleral pigmentation in the enucleated globe (25.4% vs. 53.6%, <jats:italic>p<\/jats:italic>\u2009=\u2009.0008). Histologic involvement of the episclera was also less frequent in NCTs than in CTs (39.7% vs. 76.9%, <jats:italic>p<\/jats:italic>\u2009=\u2009.008). Concurrent melanocytic neoplasms arising in melanosis were more common in NCTs (24.4%) than CTs (3.9%). Melanophages were not predominant in any samples evaluated immunohistochemically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Several popular NCT breeds carry risk for ocular melanosis, and some clinicopathologic disease features may differ from those described in CTs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13187","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T14:48:26Z","timestamp":1706194106000},"page":"266-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathologic profiles of canine ocular melanosis: A comparative study between cairn terriers and non\u2010cairn terriers"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-9439","authenticated-orcid":false,"given":"J. Seth","family":"Eaton","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison \u2013 Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanskruti S.","family":"Potnis","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison \u2013 Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Cavanaugh","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison \u2013 Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cody A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine University of Wisconsin \u2013 Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9960-678X","authenticated-orcid":false,"given":"Leandro B. C.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin, School of Veterinary Medicine University of Wisconsin \u2013 Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian C.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin, School of Veterinary Medicine University of Wisconsin \u2013 Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1259","volume-title":"Chapter\u00a021: Veterinary Ophthalmology","author":"Hendrix DVH","year":"2021"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00558.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00640.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1991.tb00851.x"},{"key":"e_1_2_10_6_1","first-page":"246","article-title":"Pigmentary glaucoma in the cairn terrier","author":"Covitz D","year":"1984","journal-title":"Transactions of the Fifteenth Annual Scientific Program of the American College of Veterinary Ophthalmologists"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2003.00306.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.1111"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12796"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12841"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305849"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2017.1287191"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2003.01706.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.283"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00739.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12572"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12170"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.129"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T06:04:17Z","timestamp":1715666657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/vop.13187"],"URL":"https:\/\/doi.org\/10.1111\/vop.13187","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]},"assertion":[{"value":"2023-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}