{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:02:04Z","timestamp":1780704124586,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the safety and efficacy of a 100 microgram subconjunctival injection of liposome\u2010encapsulated sirolimus (SCJS) to cyclosporine (CsA) or tacrolimus (CsA\/T) for the treatment of keratoconjunctivitis sicca (KCS) in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dogs with signs and symptoms of KCS were block\u2010randomized to one of two treatment groups: Biweekly SCJS or conventional treatment (CsA\/T). Schirmer tear test 1 (STT\u20101) scores, conjunctival hyperemia (CH) scores, corneal opacity (CO) scores, and clinical evaluation of potential side effects were recorded every 2\u2009weeks for 14\u2009weeks for both groups. Differences between groups were analyzed using the mixed results ANOVA and U\u2010Mann Whitney tests (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05 was considered significant).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30 eyes were included in the study, of which 20 eyes completed follow\u2010up. There was no statistically significant interaction between the treatment group and time on STT\u20101 score (<jats:italic>p\u2009=\u2009.165<\/jats:italic>), and median CH and CO scores showed no statistically significant differences between groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.353 and <jats:italic>p<\/jats:italic>\u2009=\u2009.393, respectively). There were no clinically significant side effects present in any subject at any time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this trial, a 1\u2009mg\/mL (100 micrograms) SCJS every 2\u2009weeks showed similar safety and efficacy profiles as daily CsA\/T in dogs with KS after 14\u2009weeks of treatment. Larger studies should be performed to further assess SCJS as an alternative treatment for KCS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13190","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T13:40:40Z","timestamp":1707399640000},"page":"461-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Subconjunctival liposomal sirolimus vs. cyclosporine or tacrolimus as treatment of keratoconjunctivitis sicca in dogs: A double\u2010blind, randomized study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-5222","authenticated-orcid":false,"given":"Rodrigo","family":"Garc\u00eda\u2010Santisteban","sequence":"first","affiliation":[{"name":"Hospital Veterinario Oftalvet  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica 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