{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:06:11Z","timestamp":1782227171497,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study documented the application of porcine small intestinal submucosa (SIS) as a stand\u2010alone scaffold for treating deep corneal defects in cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of 20 cats with deep stromal ulcers, perforations, or corneal sequestra that underwent surgical treatment with SIS grafts between 2021 and 2022 were retrospectively reviewed. Data on re\u2010epithelialization time, corneal transparency score, and complications were collected to analyze the reconstruction of deep corneal defects after SIS biomaterial implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All cats were unilaterally affected. The corneal defects varied in size, with a median diameter of 8.3\u2009mm (range: 3\u201315\u2009mm). Re\u2010epithelialization of the SIS graft was completed 16\u201332\u2009days after surgery (median, 22.3\u2009days). No, mild, or moderate corneal transparency was detected in 90% of the cases. Complications were observed in eight cases (40%), including aqueous leakage (10%), partial SIS malacia (25%), and persistent bullous keratopathy (5%). The follow\u2010up period ranged 90\u2013725\u2009days, with a median duration of 255\u2009days. The SIS graft was successfully applied as a single scaffold in 17 of 20 cases (85%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study suggest that the application of commercial SIS is an effective surgical technique for managing deep corneal defects in cats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13196","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T03:12:24Z","timestamp":1709089944000},"page":"264-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Application of multi\u2010layer porcine small intestinal submucosa for the reconstruction of deep corneal defects in cats"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0336-0973","authenticated-orcid":false,"given":"JingWen","family":"Luo","sequence":"first","affiliation":[{"name":"The Department of Clinical Sciences, College of 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