{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T16:17:19Z","timestamp":1780762639586,"version":"3.54.1"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine and compare the fixation strength of conjunctival pedicle flaps to cornea achieved via conventional ophthalmic suture and three different adhesive compounds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals Studied<\/jats:title><jats:p>Ex vivo porcine globes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Following a 6\u2009mm wide 500\u2010micron\u2010restricted depth lamellar keratectomy, conjunctival pedicle flaps were secured to the keratectomy site with either 8\u20100 VICRYL\u00ae suture or one of three adhesive products, including Tisseel\u00ae bioadhesive, ReSure\u00ae synthetic adhesive, or ethyl cyanoacrylate adhesive (<jats:italic>n<\/jats:italic>\u2009=\u200910 per surgical group). Adhesive application protocol varied by product based upon adhesive biocompatibility. Corneoconjunctival tissues were then harvested, clamped in a tensile testing device, and loaded at a rate of 1\u2009mm\/s under video surveillance until the point of failure. Peak load was determined for each test and used to compare fixation strength between samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty conjunctival flaps were performed, with 6 omitted from evaluation due to dehiscence prior to tensile testing. Of the 34 flaps analyzed, 10 were secured with suture, 10 with cyanoacrylate, 8 with ReSure\u00ae, and 6 with Tisseel\u00ae. Flaps secured with suture withstood significantly higher applied tensile force compared with cyanoacrylate (<jats:italic>p<\/jats:italic>\u2009=\u2009.02474), ReSure\u00ae (<jats:italic>p<\/jats:italic>\u2009=\u2009.00000), and Tisseel\u00ae (<jats:italic>p<\/jats:italic>\u2009=\u2009.00002). Flaps secured with cyanoacrylate withstood significantly greater force than those secured with ReSure\u00ae and Tisseel\u00ae (<jats:italic>p<\/jats:italic>\u2009=\u2009.01194 and 0.01798, respectively). There was no significant difference in fixation strength between ReSure\u00ae and Tisseel\u00ae glue (<jats:italic>p<\/jats:italic>\u2009=\u2009.95675).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Conjunctival pedicle flap fixation using 8\u20100 VICRYL\u00ae suture fixation was able to withstand significantly greater maximum tensile force compared to ReSure\u00ae, Tisseel\u00ae, or cyanoacrylate adhesives. Fixation strength achieved with cyanoacrylate adhesive was significantly greater than that achieved with ReSure\u00ae or Tisseel\u00ae.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13197","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T10:54:02Z","timestamp":1711450442000},"page":"253-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of conjunctival pedicle flap to corneal fixation strength achieved by Tisseel\u00ae fibrin glue, <i>ethyl<\/i> cyanoacrylate adhesive, <scp>ReSure<\/scp>\u00ae hydrogel sealant, and conventional suturing with 8\u20100 <scp>VICRYL<\/scp>\u00ae ophthalmic suture"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9760-5430","authenticated-orcid":false,"given":"Elodie M.","family":"VerHulst","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences Virginia Maryland College of Veterinary Medicine, Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-246X","authenticated-orcid":false,"given":"Roxanne M. 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