{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:08:06Z","timestamp":1747188486493,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe a novel treatment for dissolving calcareous corneal degeneration (CCD)\u2010associated mineral in 17 dogs with 13.8% ethylenediaminetetraacetic acid (EDTA) solution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases seen between 2021 and 2023 were reviewed. Seventeen dogs with CCD associated with corneal ulcerations were treated with a mineral dissolution procedure using 13.8% EDTA solution. A diamond burr keratotomy (DBK) was subsequently performed in some cases when residual mineralization remained present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 19 eyes (17 dogs) included in the study, 10 eyes (8 dogs) required a DBK procedure. One eye (one dog) required a repeat procedure 26\u2009weeks following the initial procedure and two eyes (one dog) required a repeat procedure 24 and 37\u2009weeks following initial treatment in the left and right eye, respectively. Mean follow\u2010up time to last recheck for eyes not requiring a second chelation procedure was 20.4\u2009weeks (range, 10\u201347\u2009weeks). At the last follow\u2010up examination for all 17 dogs, the CCD resolved in 26.3%, improved in 57.9%, and recurred in 15.8% of eyes. Complications occurred in two eyes (two dogs) and included an infected stromal ulcer at 2\u2010week recheck and the creation of a 40% depth stromal defect immediately following debridement. Both complications were successfully addressed with medical management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The utilization of 13.8% EDTA solution appears to be an effective and safe means of treating lesions associated with CCD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13207","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T04:44:25Z","timestamp":1710218665000},"page":"474-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dissolution of presumed calcareous corneal degeneration with 13.8% ethylenediaminetetraacetic acid solution in 17 dogs"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7811-8188","authenticated-orcid":false,"suffix":"III","given":"Richard A.","family":"Pytak","sequence":"first","affiliation":[{"name":"Eye Care for Animals\u2010Wheeling  Wheeling Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal T.","family":"Wasserman","sequence":"additional","affiliation":[{"name":"Eye Care for Animals\u2010Wheeling  Wheeling Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1082","volume-title":"Veterinary Ophthalmology","author":"Whitley RD","year":"2021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12969"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1983.tb00417.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12304"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2010.00791.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2002.00209.x"},{"key":"e_1_2_9_8_1","first-page":"1402","article-title":"Calcific band keratopathy in horses","volume":"15","author":"Rebhun WC","year":"1993","journal-title":"Compend Contin Educ Pract Vet"},{"key":"e_1_2_9_9_1","first-page":"1","article-title":"Comparison of corneal degeneration and calcific band keratopathy from 2000 to 2013 in 69 horses","volume":"1","author":"Berryhill EH","year":"2016","journal-title":"Vet Ophthalmol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.01.036"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.264"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2010.24.2.73"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00673.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00721.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2010.00799.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00024-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000159735.83295.1c"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.07.060"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T08:23:35Z","timestamp":1742199815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/vop.13207"],"URL":"https:\/\/doi.org\/10.1111\/vop.13207","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"type":"print","value":"1463-5216"},{"type":"electronic","value":"1463-5224"}],"subject":[],"published":{"date-parts":[[2024,3,11]]},"assertion":[{"value":"2023-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}