{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T06:06:30Z","timestamp":1770617190262,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the corneal clarity outcome following lamellar keratectomy of <jats:italic>arcus lipoides corneae<\/jats:italic> secondary to canine hypothyroidism and report a unique retinal manifestation of systemic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Studied<\/jats:title><jats:p>Four\u2010year\u2010old spayed female Sheepdog\u2010Poodle canine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Lamellar keratectomy OD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bilateral severe <jats:italic>arcus lipoides corneae<\/jats:italic> was noted in the initial presentation. Bilateral, symmetric, and multifocal bullous retinal detachments were observed at subsequent visits. Biochemical testing revealed hyperlipidemia presumed to be associated with primary acquired thyroiditis. Corneal clarity and visual behaviors were significantly improved following unilateral lamellar keratectomy with no evidence of recurrence within the year following surgery. Bilateral retinal detachments and hyperlipidemia resolved months after initiation of thyroxine supplementation. Corneal lipidosis in the untreated eye remained static.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lamellar keratectomy is a viable surgical option for the treatment of <jats:italic>arcus lipoides corneae.<\/jats:italic> Hypothyroidism should be considered a differential diagnosis for spontaneous, bilateral, multifocal, and serous retinal detachments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13223","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:55:22Z","timestamp":1714064122000},"page":"571-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Improved corneal clarity following lamellar keratectomy for corneal lipidosis in a canine with ocular manifestations of hypothyroidism"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5149-2602","authenticated-orcid":false,"given":"Alex P.","family":"Schenk","sequence":"first","affiliation":[{"name":"Eye Care for Animals  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annora Sheehan","family":"Gaerig","sequence":"additional","affiliation":[{"name":"Eye Care for Animals  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Reilly","sequence":"additional","affiliation":[{"name":"SpecialtyVETPATH  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.03.003"},{"key":"e_1_2_10_3_1","first-page":"2329","volume-title":"Veterinary Ophthalmology","author":"Webb AA","year":"2021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.05.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.05.002"},{"key":"e_1_2_10_6_1","first-page":"31","article-title":"Hypothyroidism associated systemic and peripheral disorders in dogs","volume":"8","author":"Srikala D","year":"2014","journal-title":"Anim Sci Report"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-015-2083-2"},{"key":"e_1_2_10_8_1","first-page":"733","article-title":"Ocular manifestations of endocrine diseases","volume":"29","author":"Plummer C","year":"2007","journal-title":"Compend Contin Educ Vet"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03245.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2007.00349.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12396"},{"key":"e_1_2_10_12_1","first-page":"1082","volume-title":"Veterinary Ophthalmology","author":"Whitley RD","year":"2021"},{"key":"e_1_2_10_13_1","first-page":"472","volume-title":"Veterinary Ocular Pathology: A Comparative Review","author":"Dubielzig RR","year":"2010"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1993.tb03522.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1989.33"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.17555\/jvc.2016.12.33.6.321"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15331"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T01:57:09Z","timestamp":1735178229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,25]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/vop.13223"],"URL":"https:\/\/doi.org\/10.1111\/vop.13223","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,25]]},"assertion":[{"value":"2023-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}