{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T03:10:33Z","timestamp":1759461033150,"version":"build-2065373602"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this report was to provide a clinical description and clinical, ultrasonographic, and histologic images of a foal with microphthalmia and multiple ocular abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals Studied<\/jats:title><jats:p>A 12\u2010h old Friesian\u2010American Paint Horse crossbred filly presented for blindness, microphthalmia and marked ventral strabismus in both eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>A complete ophthalmic examination was performed. Ultrasound biomicroscopy and B\u2010mode ultrasonography were performed. The globes were submitted for histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ultrasound biomicroscopy demonstrated a hyperechoic cornea void of the typical epithelium, stroma, and Descemet's membrane layers. The anterior chamber was spanned by thick strands of hyperechoic tissue extending from the iris to the cornea. The lens was not visualized. B\u2010mode ultrasound showed aphakia and mild, mottled echogenicity within the vitreous with no evidence of retinal detachment. On histopathology, both globes were microphthalmic with poorly defined corneal tissue. The anterior chambers were poorly formed and contained lacrimal glandular tissue. Portions of iridal tissue were present, but no lenses were noted. The retinas were segmentally detached and markedly atrophied with areas of retina dysplasia noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This report provides a clinical, ultrasonographic and histologic description of a rare, congenital condition in a foal characterized by microphthalmia, aphakia, poorly defined corneal tissue, choristomatous differentiation of the anterior segment and retinal dysplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13254","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T22:36:06Z","timestamp":1721169366000},"page":"753-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microphthalmia with multiple ocular abnormalities in a foal"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6804-4788","authenticated-orcid":false,"given":"Peter W.","family":"Cho","sequence":"first","affiliation":[{"name":"Veterinary Clinical Sciences Purdue University College of Veterinary Medicine  West Lafayette Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-2760","authenticated-orcid":false,"given":"Shin Ae","family":"Park","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences Purdue University College of Veterinary Medicine  West Lafayette Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dodd","family":"Sledge","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory Michigan State University, College of Veterinary Medicine  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Gruenwald","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory Michigan State University, College of Veterinary Medicine  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8761-9380","authenticated-orcid":false,"given":"Wendy M.","family":"Townsend","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences Purdue University College of Veterinary Medicine  West Lafayette Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"issue":"8","key":"e_1_2_8_2_1","first-page":"1725","article-title":"Microphthalmia with multiple ocular abnormalities in 11 horses: a novel syndrome","volume":"58","author":"Fragola J","year":"2017","journal-title":"Invest Ophthalmol Vis 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Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T02:51:21Z","timestamp":1759459881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/vop.13254"],"URL":"https:\/\/doi.org\/10.1111\/vop.13254","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"type":"print","value":"1463-5216"},{"type":"electronic","value":"1463-5224"}],"subject":[],"published":{"date-parts":[[2024,7,16]]},"assertion":[{"value":"2024-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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