{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:35:05Z","timestamp":1773336905765,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD023465\u201001A1"],"award-info":[{"award-number":["S10 OD023465\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY006855\u201029"],"award-info":[{"award-number":["R01EY006855\u201029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12EY015398\u201018"],"award-info":[{"award-number":["K12EY015398\u201018"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe the clinical features surgical technique, early and long\u2010term outcome with or without surgery, and histopathological findings of melanocytic anterior uveal lesions in young dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of dogs at a guide dog facility removed from training due to a pigmented iris lesion were reviewed from 2014 to 2021. Selected dogs had surgical iridectomies performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Iridal melanocytic lesions were characterized as well\u2010delineated, pigmented, and flat (nevus) or raised (mass) lesions of the iris. Forty dogs (18 Labrador retrievers, 18 German shepherd dogs, 1 Golden retriever, 3 Labrador\/Golden mixes) ranging from 0.5 to 3.1\u2009years of age were affected unilaterally (<jats:italic>n<\/jats:italic>\u2009=\u200935) or bilaterally (<jats:italic>n<\/jats:italic>\u2009=\u20095). Sector iridectomy was performed in 13 dogs with prominent and well\u2010isolated mass lesion and enucleation was carried out in 2 dogs with extensive lesions, while all other cases were monitored without surgical intervention. Postoperative complications included dyscoria (13\/13), focal posterior synechia (9\/13) and focal nonprogressive cataract (8\/13). All eyes remained visual and comfortable up to 6.2\u2009years post\u2010iridectomy with no clinically identifiable local recurrence. Histopathology was consistent with uveal melanocytoma in all samples obtained surgically. All cases that did not undergo surgery remained free of complications up to 4.5 year post diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Melanocytic anterior uveal lesions may be overrepresented in certain lineages of breeds and be present at a young age. While none of the eyes developed complications when monitored without surgery, early surgical excision of the mass by sector iridectomy yields noteworthy functional outcome and retention of a comfortable globe.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13258","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T03:04:45Z","timestamp":1722222285000},"page":"371-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical descriptive and long\u2010term outcome of melanocytic uveal lesions in young dogs: 40 cases (45 eyes) including 13 cases of sector iridectomy"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-1641","authenticated-orcid":false,"given":"Valerie Liliane","family":"Dufour","sequence":"first","affiliation":[{"name":"Section of Ophthalmology, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Canine Medicine and Surgery The Seeing Eye Inc.  Morristown New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles\u2010Antoine","family":"Assenmacher","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores M.","family":"Holle","sequence":"additional","affiliation":[{"name":"Canine Medicine and Surgery The Seeing Eye Inc.  Morristown New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy C.","family":"Durham","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo D.","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Section of Ophthalmology, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Miyadera","sequence":"additional","affiliation":[{"name":"Section of Ophthalmology, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588302000401"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300411"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12988"},{"key":"e_1_2_11_5_1","first-page":"1259","volume-title":"Veterinary Ophthalmology","author":"Hendrix DVH","year":"2021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12062"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/13536-003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00085.x"},{"key":"e_1_2_11_9_1","first-page":"471","article-title":"Melanoma of the choroid in a dog","volume":"20","author":"Aguirre GD","year":"1984","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12839"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.752"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2015.06.001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12755"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12718"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2005.12.144"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01425690701737481"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000179927.12899.bb"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12009-001-0041-x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.13187"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12519"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00603.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00924-1"},{"key":"e_1_2_11_23_1","first-page":"1173","volume-title":"Veterinary Ophthalmology","author":"Plummer CE","year":"2021"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12725"},{"key":"e_1_2_11_25_1","first-page":"1575","volume-title":"Veterinary Ophthalmology","author":"Hoffman AR","year":"2021"},{"key":"e_1_2_11_26_1","first-page":"1477","volume-title":"Veterinary Ophthalmology","author":"Petersen\u2010jones SM","year":"2020"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T08:24:19Z","timestamp":1742199859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,28]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/vop.13258"],"URL":"https:\/\/doi.org\/10.1111\/vop.13258","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,28]]},"assertion":[{"value":"2024-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}