{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:09:56Z","timestamp":1759536596067,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Investigate the tolerance, stability, and efficacy of topical 0.1% and 1% atropine in cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Six cats underwent two trials separated by a 2\u2010week washout period. One drop of artificial tears was placed in one randomly selected eye (control), and one drop of either 0.1% atropine (Trial I) or 1% atropine (Trial II) was placed in the other eye. Immediate adverse effects were recorded for severity (0\u20133) and duration (seconds). Horizontal pupil diameter (HPD), pupillary light reflexes (PLRs), intraocular pressure (IOP), Schirmer tear test\u20101 (STT\u20101), and heart rate (HR) were monitored at baseline then 8\u2009h post\u2010administration. PLRs were assessed for a total of 72\u2009h. Stability was assessed weekly for 1 month in room temperature and refrigerated conditions, evaluating solution clarity, pH, and drug concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adverse effects had a significantly lower severity score and shorter duration with 0.1% versus 1% atropine (severity 1.2\u2009\u00b1\u20090.4 vs. 2.5 \u00b1\u20090.5, <jats:italic>p<\/jats:italic>\u2009=\u2009.010; duration 107.5\u2009\u00b1\u200953.3 vs. 293.3\u2009\u00b1\u2009106.5\u2009s, <jats:italic>p<\/jats:italic>\u2009=\u2009.009). HPD was significantly greater than baseline measurements as early as 40 min for both atropine formulations. Pupils were non\u2010responsive for a significantly shorter duration with 0.1% versus 1% atropine (median 7\u2009h vs. 47.5\u2009h, <jats:italic>p<\/jats:italic> =\u2009.031). Compared with control eyes, IOP was significantly elevated by 1% atropine (<jats:italic>p<\/jats:italic>\u2009=\u2009.021) but not 0.1% atropine (<jats:italic>p<\/jats:italic>\u2009=\u2009.502). No significant differences were noted in STT\u20101 and HR measurements. Both solutions were stable in room temperature and refrigerated conditions for 1 month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diluted 0.1% atropine was stable and better tolerated by cats, offering a potential alternative to feline patients that experience adverse effects from topical 1% atropine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13268","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T01:28:50Z","timestamp":1724376530000},"page":"714-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of 0.1% and 1% atropine eyedrops in cats: A comparative study of tolerance, stability, and efficacy"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3286-0366","authenticated-orcid":false,"given":"Karin W.","family":"Handel","sequence":"first","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-3113","authenticated-orcid":false,"given":"Ron","family":"Ofri","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Goncharov","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dikla","family":"Arad","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-0127","authenticated-orcid":false,"given":"Lionel","family":"Sebbag","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"435","volume-title":"Veterinary Ophthalmology","author":"Herring IP","year":"2021"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12125"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2003.00315.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(75)90020-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1997.13.61"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.031"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.09.020"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2019.08.16"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2006.00474.x"},{"key":"e_1_2_10_11_1","first-page":"283","article-title":"Evaluation of mydriatics in the cat","volume":"9","author":"Gelatt KN","year":"1973","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.155"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4314\/ovj.v10i1.10"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15602524"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/japtr.JAPTR_72_20"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/86.6.1128"},{"volume-title":"Florid spot keratopathy in Israel. 100 canine and feline cases","year":"2024","author":"Pe'er O","key":"e_1_2_10_17_1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00927.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12138"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.75.5.494"},{"key":"e_1_2_10_21_1","first-page":"349","volume-title":"Veterinary Ophthalmology","author":"Regnier A","year":"2021"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01560"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.663212"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12804"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2004.12.016"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.12.004"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2023.05.008"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T02:51:38Z","timestamp":1759459898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/vop.13268"],"URL":"https:\/\/doi.org\/10.1111\/vop.13268","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"type":"print","value":"1463-5216"},{"type":"electronic","value":"1463-5224"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"assertion":[{"value":"2024-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}