{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:53:33Z","timestamp":1780354413166,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of topical application of 0.5% tropicamide and 1% atropine on pupil diameter (PD), intraocular pressure (IOP), and tear production (TP) in healthy pet rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals Studied<\/jats:title>\n                    <jats:p>Ten healthy client\u2010owned rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>A prospective, randomized, blinded, crossover study was conducted. Each animal received one drop of 0.5% tropicamide or 1% atropine in a randomly selected eye. PD, IOP, and TP were evaluated before drug instillation and at 0.25\u2009h, 0.5\u2009h, 0.75\u2009h, 1\u2009h, 2\u2009h, 4\u2009h, 6\u2009h, 8\u2009h, 10\u2009h, 12\u2009h, 24\u2009h, 36\u2009h, 48\u2009h, 60\u2009h, and 72\u2009h post\u2010instillation. Data were analyzed using a paired two\u2010sample repeated measures T\u2010test with Bonferroni correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In both tropicamide and atropine treated eyes, the mean PD significantly increased from 15\u2009min until 12\u2009h after treatment with a maximum PD at 45\u2009min (+2.7\u2009mm and\u2009+\u20092.4\u2009mm respectively). Following tropicamide and atropine instillation, IOP increased significantly in treated eyes at 45\u2009min (+2.9\u2009mmHg) and 15\u2009min (+5.2\u2009mmHg) respectively, compared to untreated eyes. No significant effects were found on TP, in both tropicamide and atropine treated eyes at any time. No effects were observed in the untreated eyes on any of the parameters evaluated for both drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Topical treatment with 0.5% tropicamide and 1% atropine induced mydriasis in healthy pet rabbits and could be considered as effective options when mydriatic\/cycloplegic drugs are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.13280","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T13:11:25Z","timestamp":1727442685000},"page":"948-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of topical 0.5% tropicamide and 1% atropine on pupil diameter, intraocular pressure, and tear production, in healthy pet rabbits"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4231-4764","authenticated-orcid":false,"given":"Mar\u00eda","family":"Cabrero","sequence":"first","affiliation":[{"name":"Ophthalmology Unit Atlantia Veterinary Hospital Center  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2508-2623","authenticated-orcid":false,"given":"Alexandre","family":"Guyonnet","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Atlantia Veterinary Hospital Center  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mercado","sequence":"additional","affiliation":[{"name":"FauneVet Atlantia Veterinary Hospital Center  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Andrejak\u2010Benit","sequence":"additional","affiliation":[{"name":"Statibio  Saint\u2010Fuscien 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