{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:10Z","timestamp":1787383390199,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D17CA\u2010073"],"award-info":[{"award-number":["D17CA\u2010073"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["03094\u2010MOU"],"award-info":[{"award-number":["03094\u2010MOU"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To map the disease locus for familial ocular melanosis (OM) in the Cairn Terrier.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals Studied<\/jats:title>\n                    <jats:p>Cairn Terriers with OM and normal control dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>A genome\u2010wide association study (GWAS) was performed using 63 OM\u2010affected and 31 control Cairn Terriers, followed by haplotype analysis. A significantly associated single\u2010nucleotide polymorphism was genotyped in a larger group of OM\u2010affected and control Cairn Terriers. The coding and splice\u2010site regions of genes mapping within the confidence interval were sequenced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A ~9.2\u2009Mb region of chromosome 11 was significantly associated with OM. Haplotype analysis narrowed the region to 1.49\u2009Mb. Genotyping of a SNP within the region showed 86% of OM\u2010affected dogs were homozygous or heterozygous for the risk allele, whereas 78% of unaffected dogs were homozygous for the nonrisk allele. Sequencing of the coding regions and splice sites of four genes (\n                      <jats:italic>c9orf72<\/jats:italic>\n                      ,\n                      <jats:italic>IFNK<\/jats:italic>\n                      , the 5\u2032 end of\n                      <jats:italic>MOB3B<\/jats:italic>\n                      , and the 3\u2032 end of\n                      <jats:italic>LINGO2<\/jats:italic>\n                      ) and of a microRNA (MIR876) did not detect any genetic variants unique to OM\u2010affected dogs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OM in Cairn Terriers maps to a 1.49\u2009Mb region of chromosome 11. This accounts for 86% of OM cases in our DNA bank. A second locus may account for the OM phenotype in the remaining 14% of cases. Sequencing of coding regions and splice sites of positional candidate genes and a microRNA did not reveal any genetic variants unique to affected dogs. Further studies are required to elucidate the DNA variant causal for OM in Cairn Terriers and to understand the disease mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.13291","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T09:15:23Z","timestamp":1729761323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mapping the locus for ocular melanosis in Cairn Terriers"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9646-2995","authenticated-orcid":false,"given":"Paige A.","family":"Winkler","sequence":"first","affiliation":[{"name":"Michigan State University Veterinary Medical Center  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1624-9196","authenticated-orcid":false,"given":"Ethan M.","family":"Dawson\u2010Baglien","sequence":"additional","affiliation":[{"name":"Michigan State University Veterinary Medical Center  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline C.","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Veterinary Medicine Purdue University  Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Venta","sequence":"additional","affiliation":[{"name":"Michigan State University Veterinary Medical Center  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3213-7883","authenticated-orcid":false,"given":"Kari J.","family":"Ekenstedt","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Veterinary Medicine Purdue University  Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7410-2304","authenticated-orcid":false,"given":"Simon M.","family":"Petersen\u2010Jones","sequence":"additional","affiliation":[{"name":"Michigan State University Veterinary Medical Center  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00558.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00640.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2003.00306.x"},{"key":"e_1_2_11_5_1","unstructured":"CovitzD BartholdS DitersR RiisR.Pigmentary glaucoma in the cairn terrier.1984. Transactions of the Fifteenth Annual Scientific Program of the American College of Veterinary Ophthalmologists: 246\u2013250."},{"key":"e_1_2_11_6_1","first-page":"296","article-title":"Melanocytic glaucoma in a cairn terrier","volume":"43","author":"Hanselman BA","year":"2002","journal-title":"Can Vet J"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.128.26.619-b"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-5751-12-6"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng794"},{"key":"e_1_2_11_10_1","unstructured":"IlluminaI CanineHD.BeadChip. Data Sheet: DNA Genotyping.2010."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2310"},{"key":"e_1_2_11_13_1","unstructured":"RStudio Team.RStudio: Integrated Development Environment for R.2021."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1785"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-447-0_9"},{"key":"e_1_2_11_16_1","unstructured":"MisztalI TsurutaS StrabelT AuvrayB DruetT LeeD.7th world congress on genetics applied to livestock production: 2001\u20132002.2002."},{"key":"e_1_2_11_17_1","volume-title":"Manual for BLUPF90 Family Programs","author":"Misztal I","year":"2018"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-01698-x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12122"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2006.01484.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2023.06.007"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.13291","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:31:29Z","timestamp":1787380289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/vop.13291"],"URL":"https:\/\/doi.org\/10.1111\/vop.13291","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]},"assertion":[{"value":"2024-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13291"}}