{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:29Z","timestamp":1787383409448,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2022R1A4A1025557"],"award-info":[{"award-number":["2022R1A4A1025557"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["20201 RIS\u2010001"],"award-info":[{"award-number":["20201 RIS\u2010001"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000344226"],"award-info":[{"award-number":["RS\u20102024\u201000344226"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010418","name":"Institute for Information and Communications Technology Promotion","doi-asserted-by":"publisher","award":["22A0101L1\u201011"],"award-info":[{"award-number":["22A0101L1\u201011"]}],"id":[{"id":"10.13039\/501100010418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze bacterial isolates associated with canine bacterial keratitis and their antibiotic susceptibility patterns in Korea, focusing on multidrug resistance (MDR) and identifying effective antibiotic combinations for clinical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animal studied<\/jats:title>\n                    <jats:p>A total of 146 dogs diagnosed with suspected bacterial keratitis between October 2022 and October 2023 in Korea, with 157 eye samples collected for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>Eye samples were cultured to isolate bacteria, and antibiotic susceptibility testing was performed using the minimum inhibitory concentration (MIC) method. Bacterial identification was conducted using Matrix\u2010Assisted Laser Desorption\/Ionization Time\u2010of\u2010Flight (MALDI\u2010TOF). The study assessed the efficacy of individual antibiotics and combination therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bacteria were isolated in 55.4% of the samples. The most common genera were\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      species (48.5%, 48\/99),\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      species (13.1%, 13\/99),\n                      <jats:italic>Pseudomonas<\/jats:italic>\n                      species (9.1%, 9\/99), and\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      (9.1%, 9\/99). Amikacin (84.8%) showed the highest antibiotic susceptibility, while doxycycline exhibited the lowest (17.2%). The most effective antibiotic combinations were amikacin\u2010moxifloxacin (93%). MDR isolates accounted for 52.5% (52\/99) of the total bacterial samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      species were the most common isolates, with 52.5% showing MDR, underscoring the need to curb antibiotic misuse. While antibiotics like amikacin demonstrated high susceptibility rates, their use should be reserved for resistant infections to prevent further resistance development. Rather than focusing solely on finding effective combinations of antibiotics, it is crucial to consider alternative treatment strategies that offer more sustainable solutions. Rather than relying on antibiotic combinations, attention should shift to sustainable alternatives to treat bacterial keratitis and reduce antibiotic dependence in clinical practice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.13296","type":"journal-article","created":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T21:24:32Z","timestamp":1730669072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bacterial isolates and antibiotic sensitivity in canine bacterial keratitis in Korea"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4973-7129","authenticated-orcid":false,"given":"Jiwoo","family":"Park","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-8115","authenticated-orcid":false,"given":"Donghee","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2493-7045","authenticated-orcid":false,"given":"Myeongjee","family":"Kwon","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7638-0627","authenticated-orcid":false,"given":"Hyun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1143-2471","authenticated-orcid":false,"given":"Jungyeon","family":"Yong","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4911-8469","authenticated-orcid":false,"given":"Haerin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-305X","authenticated-orcid":false,"given":"Jiyi","family":"Hwang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7293-1865","authenticated-orcid":false,"given":"Ji Seung","family":"Jung","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-6731","authenticated-orcid":false,"given":"Kyung\u2010Mee","family":"Park","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Veterinary Ophthalmology, 6th 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In Vitro antimicrobial activity of polyhexanide povidone\u2010iodine N\u2010acetylcysteine and hypochlorous acid against pathogens most commonly associated with canie and feline infectious keratitis.Presented at the ECVO.2024."},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2022-001093"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1086\/524891"},{"key":"e_1_2_11_61_1","first-page":"274","article-title":"Restricting antimicrobial use in food animals: lessons from Europe: banning nonessential antibiotic uses in food animals is intended to reduce pools of resistance genes","volume":"6","author":"Cogliani C","year":"2011","journal-title":"Microbe"},{"key":"e_1_2_11_62_1","volume-title":"Global tuberculosis report 2020","year":"2020"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.13296","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.13296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:31:27Z","timestamp":1787380287000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.13296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,3]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/vop.13296"],"URL":"https:\/\/doi.org\/10.1111\/vop.13296","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,3]]},"assertion":[{"value":"2024-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13296"}}