{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:34:56Z","timestamp":1792542896811,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Keratoconjunctivitis sicca (KCS) is characterized by decreased aqueous tear film components, leading to ocular surface damage. Diagnosis involves clinical examination, Schirmer Tear Test (STT1), and Tear Film Break\u2010Up Time (TFBUT) measurement. This retrospective study aimed to assess dry eye syndrome in intact, purebred, Aksaray Malakli breed dogs, and investigate potential associations with hereditary ocular diseases due to inbreeding for phenotype preservation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Fifty healthy, purebred, intact Aksaray Malakli dogs of varying ages and sexes, all exhibiting conjunctival hyperemia and mucoid ocular discharge. Dogs with chronic diseases, systemic medication, or ongoing ophthalmic treatment were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Demographic data, ophthalmic examination results, and ocular anomalies were recorded. STT1 and TFBUT assessments were performed to measure tear production and film stability. STT1 values were scored from 1 (normal) to 4 (severe dry eye), and TFBUT \u226520\u2009s was considered normal. Statistical analyses were used to evaluate correlations and differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The correlation between age and STT1 values (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212.182, <jats:italic>p<\/jats:italic>\u2009=\u2009.206) was not statistically significant. Mean STT1 was higher in females than males, though not significantly (<jats:italic>p<\/jats:italic>\u2009=\u2009.849). Dogs without third eyelid gland prolapse had significantly higher STT1 and TFBUT measurements compared to those with prolapse (<jats:italic>p<\/jats:italic>\u2009=\u2009.027). No significant sex difference was found in the frequency of third eyelid prolapse (<jats:italic>p<\/jats:italic>\u2009=\u2009.289). A significant positive correlation was observed between STT1 and TFBUT (<jats:italic>r<\/jats:italic>\u2009=\u2009.924; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aksaray Malakli dogs, particularly those with third eyelid gland prolapse, are predisposed to mild to moderate KCS. These findings suggest the need for further clinical and genetic investigations to better understand and manage dry eye syndrome in this breed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.13298","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T01:28:54Z","timestamp":1733966934000},"page":"802-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Keratoconjunctivitis sicca in intact Aksaray Malakli breed dogs: Evaluation of 50 cases"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-8474","authenticated-orcid":false,"given":"Nihan","family":"Avci","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Surgery Aksaray University  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1670-0709","authenticated-orcid":false,"given":"Fehmiye","family":"Gumus","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Surgery Aksaray University  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-8956","authenticated-orcid":false,"given":"Basak","family":"Boztok Ozgermen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Surgery Aksaray University  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1943-2690","authenticated-orcid":false,"given":"Dogukan","family":"Ozen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Biostatistics Ankara University  Ankara 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