{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:07Z","timestamp":1787383387961,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009944","name":"American College of Veterinary Ophthalmologists Vision for Animals Foundation","doi-asserted-by":"publisher","award":["MSN236273"],"award-info":[{"award-number":["MSN236273"]}],"id":[{"id":"10.13039\/100009944","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009944","name":"American College of Veterinary Ophthalmologists Vision for Animals Foundation","doi-asserted-by":"publisher","award":["VAF2020\u20105"],"award-info":[{"award-number":["VAF2020\u20105"]}],"id":[{"id":"10.13039\/100009944","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of latanoprostene bunod on intraocular pressure (IOP) and pupil diameter (PD) in normal cats and cats with feline congenital glaucoma (FCG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals Studied<\/jats:title>\n                    <jats:p>Five normal and 5 FCG cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>This masked, controlled crossover study comprised a 1\u2010day Pre\u2010treatment phase followed by two 10\u2010day Treatment phases, each followed by a 10\u2010day Recovery phase. During treatment, all cats received twice daily 0.005% latanoprost (LAT) or 0.024% latanoprostene bunod (LBN) in a randomized eye. Following Recovery, the same eye was treated with the opposite drug. Contralateral eyes served as saline\u2010treated controls. Intraocular pressure and PD measurements were performed three times daily during all study phases. Data were analyzed via constrained longitudinal data analysis models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Neither drug significantly reduced IOP in normal cats. In FCG cats, statistically significant reductions in mean (95% CI) IOP were observed relative to controls 4\u2009h after LAT and LBN treatment (\u22125.5\u2009mmHg [\u22128.4, \u22122.5],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001, \u22127.2\u2009mmHg [\u221210.2, \u22124.3],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001, respectively). These differences represented 28.4% and 37.9% IOP reductions, respectively. Mean IOP reduction after 4\u2009h was significantly greater with LBN treatment compared to LAT (\u22121.8\u2009mmHg [\u22123.2, \u22120.4],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.012). However, these IOP reductions were not considered clinically significant. Both drugs similarly reduced PD in normal and FCG cats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transient IOP reduction was observed after topical administration of LAT and LBN in FCG cats; and mean IOP difference was statistically significantly greater in LBN\u2010treated eyes. However, the apparent enhanced hypotensive effect of LBN is not clinically significant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.13302","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T23:34:03Z","timestamp":1732836843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of 0.024% latanoprostene bunod on intraocular pressure and pupil diameter in normal cats and cats with congenital glaucoma"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4601-0303","authenticated-orcid":false,"given":"Vanessa Y.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences School of Veterinary Medicine, University of Wisconsin \u2013 Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-9439","authenticated-orcid":false,"given":"J. Seth","family":"Eaton","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences School of Veterinary Medicine, University of Wisconsin \u2013 Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9019-2346","authenticated-orcid":false,"given":"Julie A.","family":"Kiland","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences School of Medicine and Public Health, University of Wisconsin \u2013 Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences School of Medicine and Public Health, University of Wisconsin \u2013 Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-4786","authenticated-orcid":false,"given":"Kazuya","family":"Oikawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences School of Veterinary Medicine, University of Wisconsin \u2013 Madison  Madison Wisconsin USA"},{"name":"Department of Ophthalmology and Visual Sciences School of Medicine and Public Health, University of Wisconsin \u2013 Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Hetzel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics School of Medicine and Public Health, University of Wisconsin \u2013 Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian J.","family":"McLellan","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences School of Veterinary Medicine, University of Wisconsin \u2013 Madison  Madison Wisconsin USA"},{"name":"Department of Ophthalmology and Visual Sciences School of Medicine and Public Health, University of Wisconsin \u2013 Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.17555\/jvc.2022.39.4.162"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-02995-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12678"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00912.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2015.06.010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2001.00169.x"},{"key":"e_1_2_10_8_1","unstructured":"WaldeI RappE.Feline Glaucoma. 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