{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:05Z","timestamp":1787383385790,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To describe the case of a 12\u2010year\u2010old male African lion (\n                      <jats:italic>Panthera leo<\/jats:italic>\n                      ) presented with ocular discharge, corneal edema, and buphthalmos of the right eye.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>Ocular ultrasonography showed an intraocular mass involving the iris and ciliary body. Enucleation was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subsequent histopathological analysis revealed a pleomorphic pigmented neoplastic cell population infiltrating, expanding and effacing the iris and ciliary body and occupying the ciliary cleft. The histopathological and immunohistochemical features were consistent with a diffuse iris melanoma (DIM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DIM is the most common primary intraocular neoplasm of domestic cats, but rarely reported in large felids. The prognosis in large felids is unknown and warrants identifying additional cases and careful monitoring of affected individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.13307","type":"journal-article","created":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T20:24:37Z","timestamp":1733084677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diffuse iris melanoma leading to secondary glaucoma in a lion (\n                    <i>Panthera leo<\/i>\n                    )\u2014A case report"],"prefix":"10.1111","volume":"29","author":[{"given":"Jade Caproni","family":"Correa","sequence":"first","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0173-3524","authenticated-orcid":false,"given":"Matheus Vilardo L\u00f3es","family":"Moreira","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology MVL Patologia Veterin\u00e1ria  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Lucas","family":"Javorouski","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Zool\u00f3gico do Departamento de Pesquisa e Conserva\u00e7\u00e3o da Fauna da Prefeitura Municipal de Curitiba  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Werner","sequence":"additional","affiliation":[{"name":"Werner &amp; Werner\u2014Laborat\u00f3rio de Patologia Veterin\u00e1ria  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Shaw","sequence":"additional","affiliation":[{"name":"University of Wisconin\u2010Madison Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW)  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6239-8675","authenticated-orcid":false,"given":"Barbara","family":"Schreider","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0236-5009","authenticated-orcid":false,"given":"Ricardo Guilherme","family":"D'Otaviano de Castro Vilani","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-8864","authenticated-orcid":false,"given":"Fabiano","family":"Montiani\u2010Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Universidade Federal do Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12345"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1985.186.05.505"},{"key":"e_1_2_10_4_1","first-page":"25","article-title":"Morphology and prognostic indicators of anterior uveal melanomas in cats","volume":"1","author":"Duncan PE","year":"1991","journal-title":"Progr Vet Comp Ophthalmol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/2009-0441-RAR.1"},{"key":"e_1_2_10_6_1","first-page":"1715","volume-title":"Veterinary Ophthalmology","author":"Gelatt KN","year":"2021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2006.00479.x"},{"key":"e_1_2_10_8_1","first-page":"723","article-title":"Diagnostic ophthalmology. 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