{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:05Z","timestamp":1787383385781,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the evolution of corneal sensitivity in healthy beagle puppies during the first weeks of life, compare these results with adult corneal sensitivity, and determine the age at which adult corneal sensitivity levels are reached.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals Studied<\/jats:title>\n                    <jats:p>Twelve puppies and five adult females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>Corneal sensitivity was assessed in puppies weekly from 2 to 7\u2009weeks of age and in their mothers by measuring the corneal touch threshold (CTT) in the central cornea using a Cochet\u2013Bonnet esthesiometer. Hygrometric and temperature measurements were recorded throughout the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In puppies, esthesiometry indicated a progressive decrease in corneal sensitivity with age. Sensitivity was higher between 2 and 4\u2009weeks, which stabilized between 5 and 7\u2009weeks, with a median CTT values of 0.5, 0.5, 0.8, 1.4, 1.2, and 1.4\u2009g\/mm\n                      <jats:sup>2<\/jats:sup>\n                      at 2, 3, 4, 5, 6, and 7\u2009weeks, respectively. The median CTT in puppies reached the adult median value (1.4\u2009g\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ) at 5\u2009weeks. The median CTT at 2\u2009weeks was significantly different from the median CTT at 7\u2009weeks (0.5 vs. 1.4\u2009g\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ). Humidity and temperature were not significantly associated with corneal sensitivity in adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study, corneal sensitivity in beagle puppies was higher during the first 3\u2009weeks of life compared to 7\u2009weeks. During this early period, puppies exhibited corneal sensitivity levels exceeding those of adults, which subsequently decreased to adult\u2010equivalent values between 5 and 7\u2009weeks of age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70006","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T05:41:01Z","timestamp":1739857261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010Related Variations of Corneal Sensitivity in Puppies Beagle Dogs"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-5515","authenticated-orcid":false,"given":"Sabine","family":"Chahory","sequence":"first","affiliation":[{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort, CHUVA Unit\u00e9 d'Ophtalmologie  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Maringue","sequence":"additional","affiliation":[{"name":"Ophtavet  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Huiban","sequence":"additional","affiliation":[{"name":"Mon v\u00e9to Beynes Centre Commercial de la Petite Mauldre  Beynes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7044-2205","authenticated-orcid":false,"given":"Lo\u00efc","family":"Desquilbet","sequence":"additional","affiliation":[{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort IMRB  Maisons\u2010Alfort France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.1984.tb00372.x"},{"key":"e_1_2_10_3_1","first-page":"41","volume-title":"Veterinary Ophthalmology","author":"Meekins J.","year":"2021"},{"key":"e_1_2_10_4_1","first-page":"1082","volume-title":"Veterinary Ophthalmology","author":"Whitley R.","year":"2021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2000.3230133.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(03)00050-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2011.02426.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.1.2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.1265"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000472"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2012.01069.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.56.11.844"},{"issue":"5","key":"e_1_2_10_13_1","first-page":"350","article-title":"Age\u2010Related Modifications of Corneal Sensitivity","volume":"218","author":"Roszkowska A. 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