{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:06Z","timestamp":1787383386460,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Chromatic (colorimetric) pupillary light reflexes (cPLR) are reportedly useful in canine neuro\u2010ophthalmology to differentiate sudden acquired retinal degeneration syndrome (SARDS) from optic pathway disease (neurological disorders) causing acute blindness. We report two canine cases with cPLR test results reported to be consistent with primary retinal disease that were subsequently diagnosed with optic pathway (CNS) disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals studied<\/jats:title>\n                    <jats:p>A 7\u2010year\u2010old Dachshund and a 7\u2010year\u2010old Weimaraner were presented for acute blindness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures and results<\/jats:title>\n                    <jats:p>\n                      Both dogs failed obstacle tests, showed absent menace responses, bilateral mydriasis, and absent PLRs with white light in both eyes. The cPLRs were tested using a BPI\u201050 Precision Illuminator (Retinographics Inc., USA). Both dogs exhibited no PLR with red light (660\u2009nm), and brisk though incomplete pupillary constriction with blue light (465\u2009nm) at 200 kcd\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Electroretinograms (ERG) of both eyes were normal in both dogs. Magnetic resonance imaging (MRI) of the brain revealed a left\u2010sided cystic extra\u2010axial mass (suspected meningioma) in the rostral cranial fossa in the Dachshund and a lesion affecting the rostral bones of the skull base and optic nerves in the Weimaraner (confirmed lymphoma).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These are the first two reported canine cases with acute, bilateral amaurosis due to optic pathway disease with present blue light\u2010cPLR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70010","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T14:16:15Z","timestamp":1740579375000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chromatic Pupillary Light Reflex in Two Dogs With Amaurosis Secondary to Optic Pathway Disorders"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-216X","authenticated-orcid":false,"given":"Koen","family":"Santifort","sequence":"first","affiliation":[{"name":"Evidensia Small Animal Hospital \u201cHart Van Brabant\u201d  Waalwijk the Netherlands"},{"name":"Evidensia Small Animal Hospital Arnhem  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Plonek","sequence":"additional","affiliation":[{"name":"Evidensia Small Animal Hospital Arnhem  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"G\u00f6rig","sequence":"additional","affiliation":[{"name":"Evidensia Small Animal Hospital Arnhem  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Huver","sequence":"additional","affiliation":[{"name":"Evidensia Small Animal Hospital Arnhem  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"issue":"7","key":"e_1_2_9_2_1","article-title":"Assessment of Rod, Cone, and Intrinsically Photosensitive Retinal Ganglion Cell (ipRGC) Contribution to the Canine Chromatic Pupillary Response","volume":"56","author":"Yeh C.","year":"2015","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0249"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.12-0363"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12291"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12370"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00415"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12528"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.04.020"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1372802"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117604"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2021.11.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.11.002"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"23","article-title":"The Pupillary Light Reflex in Idiopathic Intracranial Hypertension","volume":"57","author":"Park J. C.","year":"2016","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00076"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2023.1295129"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.70010","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:29:09Z","timestamp":1787380149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.70010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/vop.70010"],"URL":"https:\/\/doi.org\/10.1111\/vop.70010","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"2024-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70010"}}