{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:15Z","timestamp":1787383395571,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000344226"],"award-info":[{"award-number":["RS\u20102024\u201000344226"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["22A0101L1\u201011"],"award-info":[{"award-number":["22A0101L1\u201011"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine whether the differences in intraocular pressure (IOP) change after the topical application of 0.5% tropicamide and 0.5% phenylephrine (TP) are due to anatomical variations in the anterior chamber using ultrasound biomicroscopy (UBM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective clinical data from 27 eyes of 14 dogs with normal eye conditions were analyzed. IOP and UBM measurements were taken before and 30\u2009min after administering a topical TP. Dogs were categorized into two groups based on an IOP increase criterion of 4\u2009mmHg: the high group and the stable group. Parameters measured included the iridocorneal angle (ICA), angle\u2010opening distance (AOD), ciliary cleft width (CCW), length (CCL), area (CCA), ciliary body axial length (CBAXL), and ciliary process\u2010sclera angle (CPSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both groups showed a statistically significant decrease in ICA and an increase in AOD. However, in the stable group, CPSA increased, CBAXL decreased, and CCA increased, whereas in the high group, CPSA and CBAXL did not change significantly, and CCA decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the stable group, although the pupil dilated, the ciliary body relaxed, leading to an increase in the CCA. Conversely, in the high group, the pupil dilated, and the ciliary body remained unrelaxed, resulting in a reduction in the CCA. These iridociliary changes with pupil dilation increase the risk of elevated IOP. Therefore, an increase in IOP following TP administration may serve as a prognostic indicator for possible glaucoma risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.70015","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:19:42Z","timestamp":1742170782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intraocular Pressure Increase Induced by 0.5% Tropicamide\u20100.5% Phenylephrine in Dogs: An Analysis of Causes Using Ultrasound Biomicroscopy"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-8115","authenticated-orcid":false,"given":"Donghee","family":"Kim","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology College of Veterinary Medicine, Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8461-1455","authenticated-orcid":false,"given":"Sang\u2010Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology College of Veterinary Medicine, Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4911-8469","authenticated-orcid":false,"given":"Haerin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology College of Veterinary Medicine, Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-305X","authenticated-orcid":false,"given":"Jiyi","family":"Hwang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology College of Veterinary Medicine, Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7293-1865","authenticated-orcid":false,"given":"Ji Seung","family":"Jung","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology College of Veterinary Medicine, Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-1062","authenticated-orcid":false,"given":"Soohyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Comparative Ophthalmology, Department of Surgical and Radiological Sciences, School of Veterinary Medicine University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-6731","authenticated-orcid":false,"given":"Kyung\u2010Mee","family":"Park","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery and Ophthalmology College of Veterinary Medicine, Chungbuk National University  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007\u20101935(17)31131\u20104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-008055232-3.62815-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03\u20100704"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12196355"},{"issue":"9","key":"e_1_2_9_6_1","first-page":"3364","article-title":"The PK\u2010PD Study of Tropicamide and Phenylephrine After a Triple Ocular Instillation in Rabbits","volume":"60","author":"Zhao X.","year":"2019","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1961.01840020634005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4314\/ovj.v7i1.3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463\u20105224.2002.00226.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102415\u201012\u201053"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.116855"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2011.00898.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1968.03850040244004"},{"issue":"2","key":"e_1_2_9_14_1","first-page":"111","article-title":"Changes in Intraocular Pressure due to Cycloplegia","volume":"24","author":"Velasco Cabrera J.","year":"1998","journal-title":"CLAO Journal"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111873"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2009.00669.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.69.2.279"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1247127"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201023238\u20101"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.02.026"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1366997"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/jovr.jovr_35_18"},{"issue":"13","key":"e_1_2_9_23_1","first-page":"4465","article-title":"Comparing Change in Intraocular Pressure After Dilation With Tropicamide Alone Versus Tropicamide and Phenylephrine","volume":"47","author":"Levine J. P.","year":"2006","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.250.1.60"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7968918"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optom.2017.09.001"},{"issue":"4","key":"e_1_2_9_27_1","first-page":"361","article-title":"Diurnal Variations of Central Corneal Thickness and Intraocular Pressure in Dogs From 8:00 Am to 8:00 Pm","volume":"55","author":"Mart\u00edn\u2010Su\u00e1rez E.","year":"2014","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.1.33"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0161\u20106420(03)00623\u20107"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1997.58.10.1159"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16\u201019558"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2016.01.017"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109394(72)90459\u2010x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.12.012"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109394(43)92828\u20104"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1971.01000010014003"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318269c8d0"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120924"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u20103768.1965.tb00343.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u20103768.1968.tb02855.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2018.08.012"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.4103\/0300\u20101652.184065"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12323"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vop.70015","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.70015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:30:30Z","timestamp":1787380230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.70015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,16]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/vop.70015"],"URL":"https:\/\/doi.org\/10.1111\/vop.70015","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,16]]},"assertion":[{"value":"2024-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70015"}}